• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease.
【24h】

The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease.

机译：莫沙必利对胃食管反流病患者食管运动功能和胃酸反流的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SUMMARY: OBJECTIVE To evaluate the efficiency of the 5-HT4 agonist and 5-HT3 antagonist mosapride, as compared with cisapride, on oesophageal acid reflux variables and oesophageal motor function in patients with chronic gastro-oesophageal reflux disease (GORD).METHOD Forty-one patients with proven GORD were included in a double-blind, randomised, double-dummy, three-way crossover study. All patients received mosapride 60 mg twice daily, mosapride 30 mg three times daily, and cisapride 20 mg twice daily for seven days in a randomised order, separated by a washout period of at least five days. Twenty-three patients underwent four combined ambulatory 24-h motility and pH recordings within two weeks before the start of treatment and on day seven of each treatment period. The remaining 18 patients underwent three ambulatory 24-h pH recordings only, i.e. on treatment day seven of each treatment period.RESULTS Mosapride had no significant effect on the total number of contractions in the oesophagus, or on theeffectiveness, or possible effectiveness, of the propagations. Significant but numerically small effects on peristaltic durations and amplitudes were noted during both mosapride and cisapride treatment as compared with baseline values. The effect on acid reflux for both mosapride and cisapride was most pronounced for the duration of the longest reflux episode. The fraction of time with pH less than 4 was reduced by mosapride 30 mg three times daily in the supine position and by cisapride both totally and in the supine position. The number of reflux episodes was reduced significantly only by cisapride. Oesophageal clearance was reduced significantly by cisapride only in the supine position.CONCLUSION Mosapride had small but statistically significant effects, comparable to those of cisapride, on acid reflux variables and oesophageal motor function in patients with GORD.
机译：摘要：目的评估5-HT4激动剂和5-HT3拮抗剂莫沙必利与西沙必利相比对慢性胃食管反流病（GORD）患者食管酸反流变量和食道运动功能的有效性.METHOD 40-一项GORD证实的患者被纳入一项双盲，随机，双虚拟，三向交叉研究。所有患者均按随机顺序接受莫沙必利60毫克/天，莫沙必利30毫克/天，三次3天和西沙必利20毫克/天，每天两次，随机分组，间隔至少5天。 23例患者在开始治疗前两周内以及每个治疗期的第7天接受了4次动态24小时动态pH记录。其余18例患者仅在3个动态24小时pH记录下进行记录，即在每个治疗期的第7天进行治疗。结果莫沙必利对食道收缩总数，对食管的有效性或可能的有效性无明显影响。传播。与基线值相比，在莫沙必利和西沙必利治疗期间，对蠕动持续时间和幅度的影响均显着但在数值上很小。莫沙必利和西沙必利对酸反流的影响在最长反流发作的持续时间内最为明显。 pH值小于4的时间减少了：莫沙必利每天30 mg仰卧位每天3次，西沙必利完全和仰卧位都减少。仅西沙必利可明显减少反流发作的次数。结论仅在仰卧位使用西沙必利可明显降低食管通畅。结论莫沙必利对GORD患者的胃酸反流变量和食道运动功能具有与西沙必利相当的统计学意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号