• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >A 1 year follow-up study of the consequences of Helicobacter pylori eradication in duodenal ulcer patients: unchanged frequency of erosive oesophagitis and decreased prevalence of non-erosive gastro-oesophageal reflux disease.
【24h】

A 1 year follow-up study of the consequences of Helicobacter pylori eradication in duodenal ulcer patients: unchanged frequency of erosive oesophagitis and decreased prevalence of non-erosive gastro-oesophageal reflux disease.

机译：一项为期十二年的根除幽门螺杆菌在十二指肠溃疡患者中的后果的随访研究：糜烂性食管炎的发生频率不变，非糜烂性胃食管反流病的患病率降低。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND AIM: Discussions concerning the increased incidence of gastro-oesophageal reflux disease (GORD) after Helicobacter pylori eradication continue. In this study we aimed to evaluate the presence of co-existing GORD in (1) duodenal ulcer patients after successful H. pylori eradication, (2) patients with persistent H. pylori infection after attempts at eradication, and (3) controls in whom H. pylori eradication had not been attempted. METHODS: A prospective study of 255 patients with duodenal ulcer who were assigned to H. pylori eradication or to control treatment (omeprazole for 4 weeks) and followed up for 1 year or until peptic ulcer relapse. GORD was determined in the patients who had reflux oesophagitis on endoscopy at the beginning of the study and/or in patients without reflux oesophagitis if they experienced heartburn and/or regurgitation at least twice a week associated with impairment of daily activities. RESULTS: The study revealed a significant decrease (from 44.6% to 21.7%; P < 0.001) of patients with GORD at the end of the follow-up among those in whom H. pylori eradication had been successful. There was no significant difference in the frequency of reflux oesophagitis before and after the follow-up regardless of H. pylori status. CONCLUSIONS: H. pylori eradication did not significantly influence the prevalence and incidence of reflux oesophagitis in patients with duodenal ulcer during a 1 year follow-up period, but there was a significantly lower prevalence of GORD after successful H. pylori eradication, as patients with non-erosive GORD had been cured.
机译：背景与目的：根除幽门螺杆菌后有关胃食管反流病（GORD）发病率增加的讨论仍在继续。在这项研究中，我们旨在评估（1）根除幽门螺杆菌成功后的十二指肠溃疡患者，（2）根除尝试后持续感染幽门螺杆菌的患者以及（3）对照中共存的GORD的存在情况。尚未尝试根除幽门螺杆菌。方法：一项前瞻性研究对255例十二指肠溃疡患者进行了根除幽门螺杆菌或控制治疗（奥美拉唑治疗4周），并随访1年或直至消化性溃疡复发。在研究开始时在内窥镜检查中患有反流性食管炎的患者和/或无反流性食管炎的患者，如果他们每周至少两次经历胃灼热和/或反流与日常活动相关，则确定为GORD。结果：该研究显示，在成功结束根除幽门螺杆菌的患者中，随访结束时，GORD患者显着减少（从44.6％降至21.7％; P <0.001）。不论幽门螺杆菌状态如何，随访前后反流性食管炎的发生频率无明显差异。结论：在1年的随访期间，根除幽门螺杆菌并没有显着影响十二指肠溃疡患者反流性食管炎的发生率和发生率，但成功根除幽门螺杆菌后，GORD的患病率明显降低。非侵蚀性GORD已治愈。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号