Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives.

Liang Shengzong; Xin Dingcheng; Yang Yingbin; Xiang Jiannan

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Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives.

机译：新的13-顺-视黄基二茂铁衍生物的合成，表征和体外抗增殖活性。

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In order to improve biological behavior of the retinoyl derivatives, monoarylferrocenyl alcohols 9a and 9b were synthesized by an improved Suzuki cross-coupling method and their 13-cis-retinoic acid analogues were prepared in moderate to good yields via the Mitsunobu reaction. Their structures were confirmed by IR, (1)H NMR, (13)CNMR, MS spectra and element analysis and their antiproliferative activities were determined in vitro using human cancer cell lines. The results of bioassay showed that these organometallic analogues exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and other retinoyl derivatives.

机译：为了改善视黄酰基衍生物的生物学行为，通过改进的Suzuki交叉偶联方法合成了单芳基二茂铁基醇9a和9b，并通过Mitsunobu反应以中等至良好的产率制备了它们的13-顺-视黄酸类似物。通过IR，（1）H NMR，（13）CNMR，MS光谱和元素分析确认了它们的结构，并使用人癌细胞系在体外确定了它们的抗增殖活性。生物测定的结果表明，这些有机金属类似物显示出比母体13-顺-视黄酸和其他视黄酰基衍生物更高的抗增殖活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2009年第6期|共5页
作者
Liang Shengzong; Xin Dingcheng; Yang Yingbin; Xiang Jiannan;
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1. Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives. [J] . Liang Shengzong, Xin Dingcheng, Yang Yingbin, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第6期

机译：新的13-顺-视黄基二茂铁衍生物的合成，表征和体外抗增殖活性。
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Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives.

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