TDAE-assisted synthesis of new imidazo(2,1-b)thiazole derivatives as anti-infectious agents.

Juspin T; Laget M; Terme T; Azas N; Vanelle P

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TDAE-assisted synthesis of new imidazo(2,1-b)thiazole derivatives as anti-infectious agents.

机译：TDAE辅助合成新的咪唑并（2,1-b）噻唑衍生物作为抗感染剂。

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A series of new imidazo[2,1-b]thiazoles was prepared in moderate to good yields in a four step synthesis using the TDAE methodology from 6-chloromethyl-5-nitroimidazo[2,1-b]thiazole and keto esters, ketomalonates and ketolactams. All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two Gram positive and two Gram negative ones) and four yeasts. Among these synthesized 5-nitroimidazo[2,1-b]thiazoles, the compounds 1 and 6 showed potent antimicrobial activities against all candida strains and compound 3e showed an interesting antifungal potential against Candida tropicalis.

机译：使用TDAE方法，通过四步合成，从6-氯甲基-5-硝基咪唑并[2,1-b]噻唑和酮酸酯，酮缩酮中制备了一系列新型的咪唑并[2,1-b]噻唑和酮内酰胺。测试了所有化合物对四种细菌菌株（两种革兰氏阳性和两种革兰氏阴性）和四种酵母菌的抗菌和抗真菌活性。在这些合成的5-硝基咪唑并[2,1-b]噻唑类化合物中，化合物1和6对所有念珠菌菌株均显示出有效的抗菌活性，而化合物3e对热带念珠菌显示出有趣的抗真菌潜力。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第2期|共6页
作者
Juspin T; Laget M; Terme T; Azas N; Vanelle P;
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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. TDAE-assisted synthesis of new imidazo(2,1-b)thiazole derivatives as anti-infectious agents. [J] . Juspin T, Laget M, Terme T, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第2期

机译：TDAE辅助合成新的咪唑并（2,1-b）噻唑衍生物作为抗感染剂。
2. Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors [J] . Samala Ganesh, Devi Parthiban Brindha, Saxena Shalini, Bioorganic and medicinal chemistry . 2016,第6期

机译：咪唑并[2,1-b]噻唑和苯并[d]咪唑并[2,1-b]噻唑衍生物作为结核分枝杆菌泛酸合成酶抑制剂的设计，合成及生物学评价
3. Synthesis of Some Novel Fused Imidazo [2, 1-b] [1, 3] Thiazole and Imidazo [2, 1-b] Thiazolo [5, 4-d] Isoxazole Derivatives [J] . Hamid RezaJaberi, HadiNoorizadeh Journal of Chemistry . 2012,第3期

机译：一些新型新型融合咪唑的合成[2,1-B] [1,3]噻唑和咪唑吡唑[2,1-B]异恶唑衍生物
4. Synthesis and toxicological activity of 5-nitroindazole sulfonamides derivatives as potential antimicrobial agents. Optimization of the synthesis [C] . Corina Cheptea, Andreea-Celia Benchea, Marius Găină, 2017 E-Health and Bioengineering Conference . 2017

机译：5-硝基吲唑磺酰胺衍生物作为潜在抗菌剂的合成及其毒理活性。优化合成
5. Synthesis of Novel Thiazole and Pyrazole Derivatives as Antimicrobial and Anticancer Agents [D] . Khan, Md Mahbub Kabir. 2020

机译：新型噻唑和吡唑衍生物作为抗微生物和抗癌剂的合成
6. Fluorinated Derivatives of Benz45imidazo12-b13 thiazole—Inhibitors of Reproduction of Measles Virus [O] . A. G. Pokrovskii, T. N. Ilicheva, S. K. Kotovskaya, -1

机译：苯并45咪唑并12-b 13噻唑的氟代衍生物—麻疹病毒繁殖抑制剂
7. Studies on Thiocyanation of Heterocyclic Compounds. II. : Thiocyanation of Imidazo 2, 1-b thiazole Derivatives (Organic) [O] . SABURO KANO 1972

机译：杂环化合物硫氰化合物的研究。 II。：咪唑硫氰化2,1-B噻唑衍生物（有机）

TDAE-assisted synthesis of new imidazo(2,1-b)thiazole derivatives as anti-infectious agents.

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