Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity.

Ismail MM; Rateb HS; Hussein MM

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity.

【24h】

Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity.

机译：具有抗癌活性的新型苯并吡喃-2-酮的合成与对接研究。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Novel series of 7-substituted-benzopyran-2-ones was synthesized by incorporating heterocyclic rings as oxadiazole, triazole, pyrazole or pyrazolin-5-one to benzopyran-2-one nucleus at p-7 via methylene-oxy or acetoxy linker. In-vitro anticancer activity was evaluated for these hybrids; twelve compounds were selected by National Cancer Institute for anticancer screening. Among them, compound 9a exhibited broad spectrum antitumor activity showing full panel median growth inhibition (GI(50)) = 5.46 microM. According to docking results using Molsoft ICM 3.4-8c program, the target compounds may act through inhibition of topoismerase 1, where camptothecin is used as ligand.

机译：通过将杂环如恶二唑，三唑，吡唑或吡唑啉-5-酮通过亚甲基-氧或乙酰氧基连接到p-7的苯并吡喃-2-酮核上，合成了一系列新的7-取代-苯并吡喃-2-酮。对这些杂种的体外抗癌活性进行了评估。美国国家癌症研究所选择了十二种化合物进行抗癌筛选。其中，化合物9a表现出广谱抗肿瘤活性，显示出全面板中位生长抑制（GI（50））= 5.46 microM。根据使用Molsoft ICM 3.4-8c程序进行的对接结果，目标化合物可能通过抑制拓扑磷酸酶1发挥作用，其中喜树碱用作配体。

著录项

来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第9期|共10页
作者
Ismail MM; Rateb HS; Hussein MM;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医药、卫生;劳动卫生;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity. [J] . Ismail MM, Rateb HS, Hussein MM European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第9期

机译：具有抗癌活性的新型苯并吡喃-2-酮的合成与对接研究。
2. Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies [J] . Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah Sfouq Aleanizy, Saudi Pharmaceutical Journal . 2019,第5期

机译：5,5-二苯基咪唑烷-2,4-二酮衍生物的合成，抗癌，诱导细胞凋亡的活性以及EGFR和VEGFR2测定机理的研究：分子对接研究
3. Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity. [J] . Moutevelis Minakakis P, Papavassilopoulou E, Michas G, Bioorganic and medicinal chemistry . 2011,第9期

机译：新的2-吡咯烷酮衍生物的合成，计算机对接实验及其抗炎活性的研究。
4. Benzofuran-3(2H)-Ones Derivatives: Synthesis, Docking and Evaluation of Their in Vitro Anticancer Studies [C] . Nishant Verma, Shaily, Kalpana Chauhan, International Conference on Trends in Computational and Cognitive Engineering . 2020

机译：Benzofuran-3（2H） - 衍生物：其体外抗癌研究的合成，对接和评估
5. I. Steric effects in the synthesis of 2,3-dihydro-4-(1H)-quinolinones by the tandem Michael-SNAr reaction. II Synthesis of nitrogen heteroarotinoids for anticancer activity. III. Synthetic study of supramolecular compounds [D] . Abuskhuna, Suaad M. 2013

机译：I.通过串联Michael-SNAr反应合成2，3-二氢-4-（1H）-喹啉酮的立体效应。 II。合成氮杂芳烃类化合物具有抗癌活性。三，超分子化合物的合成研究
6. Synthesis anticancer apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 55-diphenylimidazolidine-24-dione derivatives: Molecular docking studies [O] . Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah Sfouq Aleanizy, 2019

机译：55-二苯基咪唑烷-24-二酮衍生物的合成抗癌诱导细胞凋亡的活性以及EGFR和VEGFR2测定机理的研究：分子对接研究
7. Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies [O] . Abdulmalik S. Altamimi, Adel S. El-Azab, Sami G. Abdelhamid, 2021

机译：合成，抗癌筛选一些新型三甲氧基喹唑啉和VEGFR2，EGFR酪氨酸激酶抑制剂测定;分子对接研究

Synthesis and docking studies of novel benzopyran-2-ones with anticancer activity.

摘要

著录项

相似文献

相关主题

期刊订阅