Discovery of highly potent agents against influenza A virus.

Zhao X; Li C; Zeng S; Hu W

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Discovery of highly potent agents against influenza A virus.

机译：发现了针对甲型流感病毒的高效药物。

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We previously reported several new M2 inhibitors as active as amantadine against influenza A virus and validated by three types of in vitro assays. Herein, we further modified one of the most potent hits in a viral inhibition assay and conducted structure-activity relationship studies on this scaffold. As a result, compound 8e was identified to be the most potent inhibitor against wild-type influenza A virus, being nearly 240-fold more active than amantadine.

机译：我们以前曾报道过几种新的M2抑制剂，它们对金刚烷胺具有抗A型流感病毒的活性，并已通过三种体外试验进行了验证。在本文中，我们进一步修饰了病毒抑制试验中最有效的命中之一，并对该支架进行了结构-活性关系研究。结果，化合物8e被鉴定为最有效的抗野生型A型流感病毒的抑制剂，其活性比金刚烷胺高近240倍。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2011年第1期|共6页
作者
Zhao X; Li C; Zeng S; Hu W;
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正文语种 eng
中图分类药学;
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Discovery of highly potent agents against influenza A virus.

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