Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.

Aly MM; Mohamed YA; El Bayouki KA; Basyouni WM; Abbas SY

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Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.

机译：某些新的4（3H）-喹唑啉酮-2-羧甲醛硫代半脲酮及其金属配合物的合成及其抗惊厥，止痛，细胞毒性和抗菌活性的研究-第1部分。

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Novel 3-aryl-4(3H)-quinazolinone-2-carboxaldehydes, their corresponding Schiff's base and thiosemicarbazone derivatives were synthesized from the starting 5-iodo anthranilic acid. Copper(II), zinc(II) complexes of some thiosemicarbazone derivatives were also synthesized and characterized. Screening for some selected compounds was carried out to probe their potential anticonvulsant, analgesic, cytotoxic as well as their antimicrobial activities.

机译：从起始的5-碘邻氨基苯甲酸合成了新型的3-芳基-4（3H）-喹唑啉酮-2-甲醛，它们相应的席夫碱和硫代半脲衍生物。还合成并表征了一些硫代半脲酮衍生物的铜（II），锌（II）配合物。进行了一些选定化合物的筛选，以探查其潜在的抗惊厥药，止痛药，细胞毒性药物及其抗菌活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第8期|共9页
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Aly MM; Mohamed YA; El Bayouki KA; Basyouni WM; Abbas SY;
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1. Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. [J] . Aly MM, Mohamed YA, El Bayouki KA, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第8期

机译：某些新的4（3H）-喹唑啉酮-2-羧甲醛硫代半脲酮及其金属配合物的合成及其抗惊厥，止痛，细胞毒性和抗菌活性的研究-第1部分。
2. Metal-based antitumor, cytotoxic and antimicrobial activity: pharmacological evaluation of Knoevenagel condensate β-diketone Schiff base thiosemicarbazone Cu(II) and Zn(II) complexes [J] . N. Raman, R. Jeyamurugan, B. Rajkapoor Applied Organometallic Chemistry . 2009,第7期

机译：基于金属的抗肿瘤，细胞毒性和抗微生物活性：诺文AGEL缩合物β-二酮席夫碱硫代半脲铜（II）和锌（II）配合物的药理评价
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6. Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity [O] . Tudor Rosu, Aurelian Gulea, Anca Nicolae, 2007

机译：3dn金属离子与硫代氨基脲的配合物：合成和抗菌活性。
7. Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity [O] . Tudor Rosu, Aurelian Gulea, Anca Nicolae, 2007

机译：3dn金属离子与缩氨基硫脲的配合物：合成和抗菌活性

Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.

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