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首页> 外文期刊>European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie >Rapamycin safeguards lymphocytes from DNA damage accumulation in vivo
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Rapamycin safeguards lymphocytes from DNA damage accumulation in vivo

机译：雷帕霉素可保护淋巴细胞免受体内DNA损伤的积累

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摘要

Several studies reported the benefits of switching from anticalcineurins to mTOR inhibitors to avoid cancer occurrence after organ transplantation. The purpose of our study was to determine in vivo biological markers to explain these benefits. Cellular changes related to cellular senescence and DNA damage were analyzed in peripheral blood lymphocytes. Thirty-five kidney transplanted patients receiving anticalcineurins were investigated: 17 patients were proposed to switch to rapamycin and 18 patients with similar age and transplantation duration, continued anticalcineurins. Rapamycin effects were studied one year after the switch. Thirteen healthy volunteers and 18 hemodialyzed patients were evaluated as control.
机译：几项研究报告了从抗神经尿素转换为mTOR抑制剂的益处，以避免器官移植后发生癌症。我们研究的目的是确定体内生物学标记以解释这些益处。在外周血淋巴细胞中分析了与细胞衰老和DNA损伤有关的细胞变化。对35名接受抗神经尿素的肾移植患者进行了调查：建议改用雷帕霉素治疗17例患者，年龄和移植时间相似的18例患者继续应用抗神经尿素。转用一年后研究了雷帕霉素的作用。 13名健康志愿者和18名血液透析患者被评估为对照组。

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