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The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.

机译:心理压力对免疫调节平衡的不利影响:应用于人类炎症性疾病。

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摘要

Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.
机译:心理压力对免疫系统具有已知的影响,包括影响效应子和调节成分。这可能导致对各种感染的敏感性增加,潜在的病毒重新激活以及对免疫调节回路的影响。转化研究的最大挑战之一是确定特定患者人群和个体与压力相关的风险。未来的研究必须包括生物标志物的鉴定和验证,这些标志物可以将患者因各种形式和程度的心理压力而产生的不良免疫影响的风险分类,以及如何影响其炎症性疾病的进程。

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