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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease.
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CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease.

机译：CD8 + CD28-和CD8 + CD57 + T细胞及其在健康和疾病中的作用。

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摘要

Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or CD8(+) CD57(+) T lymphocytes. There is growing evidence that the CD8(+) CD28(-) (CD8(+) CD57(+)) T-cell population plays a significant role in various diseases or conditions, associated with chronic immune activation such as cancer, chronic intracellular infections, chronic alcoholism, some chronic pulmonary diseases, autoimmune diseases, allogeneic transplantation, as well as has a great influence on age-related changes in the immune system status. CD8(+) CD28(-) (CD8(+) CD57(+)) T-cell population is heterogeneous and composed of various functionally competing (cytotoxic and immunosuppressive) subsets thus the overall effect of CD8(+) CD28(-) (CD8(+) CD57(+)) T-cell-mediated immunity depends on the predominance of a particular subset. Many articles claim that CD8(+) CD28(-) (CD8(+) CD57(+)) T cells have lost their proliferative capacity during process of replicative senescence triggered by repeated antigenic stimulation. However recent data indicate that CD8(+) CD28(-) (CD8(+) CD57(+)) T cells can transiently up-regulate telomerase activity and proliferate under certain stimulation conditions. Similarly, conflicting data is provided regarding CD8(+) CD28(-) (CD8(+) CD57(+)) T-cell sensitivity to apoptosis, finally leading to the conclusion that this T-cell population is also heterogeneous in terms of its apoptotic potential. This review provides a comprehensive approach to the CD8(+) CD28(-) (CD8(+) CD57(+)) T-cell population: we describe in detail its origins, molecular and functional characteristics, subsets, role in various diseases or conditions, associated with persistent antigenic stimulation.
机译：慢性抗原刺激会导致晚期分化的，抗原特异性的寡克隆T细胞逐渐积累，尤其是在CD8（+）T细胞区室中。它们的特征在于严重缩短的端粒，CD28的丢失和/或CD57表达的增加，并且被定义为CD8（+）CD28（-）或CD8（+）CD57（+）T淋巴细胞。越来越多的证据表明，CD8（+）CD28（-）（CD8（+）CD57（+））T细胞群体在各种疾病或状况中起着重要作用，这些疾病或状况与诸如癌症，慢性细胞内感染等慢性免疫激活有关，慢性酒精中毒，某些慢性肺部疾病，自身免疫性疾病，同种异体移植以及对与年龄相关的免疫系统状态变化具有很大影响。 CD8（+）CD28（-）（CD8（+）CD57（+））T细胞群体是异质的，由各种功能竞争的（细胞毒性和免疫抑制性）亚组组成，因此CD8（+）CD28（-）的总体作用（ CD8（+）CD57（+））T细胞介导的免疫力取决于特定子集的优势。许多文章声称，CD8（+）CD28（-）（CD8（+）CD57（+））T细胞在反复抗原刺激触发的复制衰老过程中失去了增殖能力。但是，最近的数据表明CD8（+）CD28（-）（CD8（+）CD57（+））T细胞可以瞬时上调端粒酶活性并在某些刺激条件下增殖。同样，关于CD8（+）CD28（-）（CD8（+）CD57（+））T细胞对细胞凋亡的敏感性，也提供了相互矛盾的数据，最后得出结论，该T细胞群体在其T细胞群体方面也具有异质性凋亡潜力。这篇综述为CD8（+）CD28（-）（CD8（+）CD57（+））T细胞群提供了全面的研究方法：我们详细描述了其起源，分子和功能特征，亚群，在各种疾病或疾病中的作用与持续的抗原刺激有关的疾病。

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