...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.
【24h】

CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.

机译：CD45负调节树突状细胞中的肿瘤坏死因子和白介素6的产生。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and splenic dendritic cells (sDC), is increased following stimulation via Toll-like receptor (TLR)3 and TLR9. Nuclear factor-kappaB activation, an important downstream consequence of TLR3 and TLR9 signalling, is also increased in CD45-/- BMDC. BMDC of CD45-/- mice also produce more TNF and IL-6 following stimulation with the cytokines TNF and interferon-alpha. These results show that TLR signalling is increased in CD45-/- dendritic cells and imply that CD45 is a negative regulator of TLR and cytokine receptor signalling in dendritic cells.
机译：已知CD45可以通过多种造血细胞类型中的许多不同表面受体调节信号传导。在这里，我们首次报道CD45-/-骨髓树突状细胞（BMDC）比CD45 + / +细胞更活化，并且BMDC和脾树突状细胞产生肿瘤坏死因子（TNF）和白介素6（IL-6）。通过Toll样受体（TLR）3和TLR9刺激后，细胞（sDC）的含量增加。在CD45-/-BMDC中，核因子-κB激活（TLR3和TLR9信号转导的重要下游结果）也有所增加。在用细胞因子TNF和干扰素-α刺激后，CD45-/-小鼠的BMDC也产生更多的TNF和IL-6。这些结果表明，TLR信号在CD45-/-树突状细胞中增加，并且暗示CD45是树突状细胞中TLR和细胞因子受体信号转导的负调节剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号