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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Immunological research using RNA interference technology.
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Immunological research using RNA interference technology.

机译：使用RNA干扰技术的免疫学研究。

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摘要

RNA interference (RNAi) is a potent method of gene silencing that has developed rapidly over the past few years as a result of its extensive importance in the study of genetics, molecular biology and physiology. RNAi technology has also recently yielded significant insight into the innate and adaptive immune systems by helping to elucidate numerous mechanisms that regulate the development, activation and function of cells that mediate immunity. In addition, because of its ability to suppress gene expression effectively, this technique may be used to regulate the immune response for clinical purposes. Nonetheless, before RNAi can be successfully administered into human patients as a medical treatment, it is necessary to overcome several major limitations of this technology, such as inefficient in vivo delivery, incomplete silencing of target genes, non-specific immune responses, and off-target effects. As novel developments and discoveries in molecular biology swiftly continue to unfold, it is likely that RNAi may soon translate into a potent form of in vivo gene silencing with profound applications to vaccination and immunotherapy. In the present review, we examine the current progress of immunological studies employing RNAi and discuss the prospects for the implementation of this technique in the clinical arena.
机译：RNA干扰（RNAi）是一种有效的基因沉默方法，由于其在遗传学，分子生物学和生理学研究中的广泛重要性，近几年来发展迅速。 RNAi技术最近还通过帮助阐明调节介导免疫力的细胞的发育，激活和功能的众多机制，也对先天性和适应性免疫系统产生了深刻的了解。另外，由于其有效抑制基因表达的能力，该技术可用于调节免疫应答以用于临床目的。但是，在将RNAi成功地用于人类患者之前，必须克服该技术的几个主要限制，例如体内递送效率低下，靶基因沉默不完全，非特异性免疫反应以及脱机。目标效果。随着分子生物学的新发展和发现继续迅速发展，RNAi可能很快会转化为有效的体内基因沉默形式，并在疫苗接种和免疫疗法中得到广泛应用。在本综述中，我们检查了采用RNAi的免疫学研究的最新进展，并讨论了在临床领域实施该技术的前景。

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