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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Profiling leucocyte subsets in tuberculosis-diabetes co-morbidity
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Profiling leucocyte subsets in tuberculosis-diabetes co-morbidity

机译：结核-糖尿病合并症中白细胞亚群的分析

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摘要

The immune system plays an important role in the pathogenesis of pulmonary tuberculosis-type 2 diabetes mellitus (PTB-DM) co-morbidity. However, the phenotypic profile of leucocyte subsets at homeostasis in individuals with active or latent tuberculosis (LTB) with coincident diabetes is not known. To characterize the influence of diabetes on leucocyte phenotypes in PTB or LTB, we examined the frequency (F-o) of leucocyte subsets in individuals with TB with (PTB-DM) or without (PTB) diabetes; individuals with latent TB with (LTB-DM) or without (LTB) diabetes and non-TB-infected individuals with (NTB-DM) or without (NTB) diabetes. Coincident DM is characterized by significantly lower F-o of effector memory CD4(+) T cells in LTB individuals. In contrast, DM is characterized by significantly lower F-o of effector memory CD8(+) T cells and significantly higher F-o of central memory CD8(+) T cells in PTB individuals. Coincident DM resulted in significantly higher F-o of classical memory B cells in PTB and significantly higher F-o of activated memory and atypical B cells in LTB individuals. Coincident DM resulted in significantly lower F-o of classical and intermediate monocytes in PTB, LTB and NTB individuals. Finally, DM resulted in significantly lower F-o of myeloid and plasmacytoid dendritic cells in PTB, LTB and NTB individuals. Our data reveal that coincident diabetes alters the cellular subset distribution of T cells, B cells, dendritic cells and monocytes in both individuals with active TB and those with latent TB, thus potentially impacting the pathogenesis of this co-morbid condition.
机译：免疫系统在肺结核2型糖尿病（PTB-DM）合并症的发病机理中起着重要作用。然而，活动性和潜伏性肺结核（LTB）并发糖尿病的个体体内稳态时白细胞亚群的表型特征尚不清楚。为了表征糖尿病对PTB或LTB中白细胞表型的影响，我们检查了患有（PTB-DM）或不患有（PTB）糖尿病的TB患者中白细胞亚群的频率（F-o）。患有（LTB-DM）或没有（LTB）糖尿病的潜在结核病患者和（NTB-DM）或没有（NTB）糖尿病的非结核病感染患者。巧合DM的特征是LTB个体中效应记忆CD4（+）T细胞的F-o明显较低。相比之下，DM的特征是效应记忆性CD8（+）T细胞的F-o显着降低，而PTB个人的中央记忆CD8（+）T细胞的F-o显着更高。巧合的DM导致PTB中经典记忆B细胞的F-o显着升高，而LTB个体中激活记忆和非典型B细胞的F-o显着较高。巧合的DM导致PTB，LTB和NTB个体的经典和中间单核细胞的F-o大大降低。最后，DM导致PTB，LTB和NTB个体的髓样和浆细胞样树突状细胞的F-o明显降低。我们的数据显示，同时发生的糖尿病会改变患有活动性结核病的人和患有潜伏性结核病的人的T细胞，B细胞，树突状细胞和单核细胞的细胞亚群分布，从而可能影响这种合并症的发病机理。

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