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首页> 外文期刊>European Polymer Journal >Supramolecular structures from self-assembled poly(gamma-benzyl-L-glutamate)-polydimethylsiloxane-poly(gamma-benzyl-L- glutamate) triblock copolypeptides in thin films
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Supramolecular structures from self-assembled poly(gamma-benzyl-L-glutamate)-polydimethylsiloxane-poly(gamma-benzyl-L- glutamate) triblock copolypeptides in thin films

机译：自组装聚（γ-苄基-L-谷氨酸）-聚二甲基硅氧烷-聚（γ-苄基-L-谷氨酸）三嵌段共肽的超分子结构

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摘要

We describe the self-assembly of A-B-A triblock copolymers in thin films composed of a soft polydimethylsiloxane (PDMS) central block (B) and two polypeptidic (A) blocks, poly(gamma-benzyl)-L-glutamate (PBLG). The PBLG segment exhibits depending on the chain length two distinct secondary conformations either a beta-sheet or a alpha-helical conformation. The direct relationship between the surface morphology and the secondary conformation of the polypeptide segment has been evidenced by atomic force microscopy. For chain lengths below 20 U the polypeptide segments adopt preferentially a beta-sheet secondary structure and the triblock copolymer self-assembled in fibers. Moreover, the fiber diameters increased with the chain length of the triblock copolymer. For chain lengths above 20, the alpha-helical structure is stabilized and a lamellar morphology is formed driven by rod-rod interactions in spite of the very asymmetric composition of the triblock copolymer. However, decreasing the film thickness from 25 to 8 nm, i.e., below the L/2 and due to the preferential attraction of the polypeptide block for the hydrophilic substrate employed, instead of a lamellar morphology a rod-like morphology could be found. Thus, the use of hybrid block copolymer containing polypeptides with particular secondary structures offers novel alternatives to control the self-assembly in thin films compared to traditional amorphous block copolymers.
机译：我们描述了由软聚二甲基硅氧烷（PDMS）中心嵌段（B）和两个多肽（A）嵌段，聚（γ-苄基）-L-谷氨酸（PBLG）组成的薄膜中A-B-A三嵌段共聚物的自组装。 PBLG链段根据链长表现出两个不同的二级构象，即β折叠或α螺旋构象。表面形态和多肽片段的二级构象之间的直接关系已经通过原子力显微镜证实。对于小于20U的链长，多肽片段优选采用β-折叠二级结构，并且三嵌段共聚物自组装在纤维中。而且，纤维直径随三嵌段共聚物的链长而增加。对于大于20的链长，尽管三嵌段共聚物的组成非常不对称，但α-螺旋结构稳定并且由杆-杆相互作用驱动形成层状形态。然而，将膜厚度从25nm降​​低至8nm，即，在L / 2以下，并且由于多肽嵌段对所用的亲水性底物的优先吸引，可以发现棒状形态代替层状形态。因此，与传统的无定形嵌段共聚物相比，使用含有具有特定二级结构的多肽的杂化嵌段共聚物提供了控制薄膜中自组装的新选择。

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