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首页> 外文期刊>European psychiatry: the journal of the Association of European Psychiatrists >Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes
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Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes

机译：氧化应激参数中基于性别的差异并不构成两性之间情绪障碍易感性的差异

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The present study aimed to determine whether any gender-related difference exists concerning oxidative stress parameters in a population of 231subjects, and if these changes might be related to gender-associated differences in major depressive disorder (MDD) or bipolar disorder (BD) vulnerability. This is a case-control nested in a population-based study. The initial psychopathology screen was performed with the Mini-International Neuropsychiatric Interview and the diagnostic was further confirmed with the Structured Clinical Interview for DSM-IV. Blood samples were obtained after the interview and the oxidative stress parameters such as uric acid, advanced oxidation protein product (PCC) and lipid hydroperoxides (TBARS) were determined. Our results indicated a higher prevalence of MDD and BD in women when compared to men. In addition, significant gender differences were found in the levels of PCC (0.27 ± 0.27 vs. 0.40 ± 0.31. nmol CO/mg protein, men vs. women, respectively; P= 0.02) and uric acid (4.88 ± 1.39. mg/dL vs. 3.53 ± 1.02. mg/dL, men vs. women, respectively; P= 0.0001), but not in TBARS (0.013 ± 0.01. nmol/mg of protein vs. 0.017 ± 0.02. nmol/mg of protein, men vs. women respectively; P= 0.243). After sample stratification by gender, no association was found between oxidative stress parameters and clinical diagnosis of MDD and BD for women (P= 0.516 for PCC; P= 0.620 for TBARS P= 0.727 for uric acid) and men (P= 0.367 for PCC; P= 0.372 for TBARS P= 0.664 for uric acid). In this study, women seem more susceptible to oxidative stress than male. However, these gender-based differences do not seem to provide a biochemical basis for the epidemiologic differences in mood disorders susceptibility between sexes.
机译：本研究旨在确定在231名受试者中是否存在与氧化应激参数有关的任何性别相关差异，以及这些变化是否可能与主要抑郁症（MDD）或双相情感障碍（BD）易感性的性别相关差异有关。这是一个病例对照，嵌套在基于人群的研究中。最初的心理病理学筛查是通过Mini-International Neuropsychiatric访谈进行的，诊断是通过DSM-IV的结构化临床访谈进一步确认的。访谈后获得了血液样本，并测定了氧化应激参数，例如尿酸，高级氧化蛋白产物（PCC）和脂质氢过氧化物（TBARS）。我们的结果表明，与男性相比，女性的MDD和BD患病率更高。此外，在PCC（0.27±0.27 vs. 0.40±0.31。nmol CO / mg蛋白，分别为男性与女性; P = 0.02）和尿酸（4.88±1.39。mg / dL vs. 3.53±1.02。mg / dL，分别为男性与女性; P = 0.0001），但未在TBARS中显示（0.013±0.01。nmol / mg蛋白质与0.017±0.02。nmol / mg蛋白质，男性分别与女性相比; P = 0.243）。按性别分层后，女性（男性P = 0.516; TBARS P = 0.620;尿酸P = 0.727）和男性（PCC P = 0.367）的氧化应激参数与MDD和BD的临床诊断之间没有关联。 ;对于TBARS，P = 0.372;对于尿酸，P = 0.664）。在这项研究中，女性似乎比男性更容易受到氧化应激。但是，这些基于性别的差异似乎并未为两性之间情绪障碍易感性的流行病学差异提供生化基础。

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