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Epigenetic and genetic alterations-based molecular classification of head and neck cancer

机译：基于表观遗传和遗传改变的头颈癌分子分类

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The long-term survival rates for patients diagnosed with advanced head and neck cancer (HNC) remain poor. Many perplexing factors, including etiology and comorbidity, lead to different molecular malfunctions of HNC cells and determine the prognosis of the disease. Traditional diagnostic methods are limited in that they fail to provide an effective classification diagnosis, such as a more precise prediction of prognosis and decisions for personalized treatment regimens. Recently, molecular biology techniques, especially epigenetic and genetic techniques, have been developed that have enabled us to gain a greater insight into the molecular pathways underlying the cancers. Translating the research into a format that will facilitate effective molecular classification, support personalized treatment and determine prognosis remains a challenge. In this review, the authors provide an overview of cancer epigenetic and genetic alterations, tissue banks, and several promising biomarkers or candidates that may ultimately prove to be beneficial in a clinical setting for patients with HNC.
机译：诊断为晚期头颈癌（HNC）的患者的长期生存率仍然很差。许多复杂的因素，包括病因和合并症，导致HNC细胞发生不同的分子功能异常，并决定了该疾病的预后。传统诊断方法的局限性在于它们无法提供有效的分类诊断，例如无法更准确地预测预后以及针对个性化治疗方案的决策。最近，已经开发了分子生物学技术，尤其是表观遗传学和遗传技术，使我们能够更深入地了解癌症的分子途径。将研究转化为有助于有效的分子分类，支持个性化治疗并确定预后的格式仍然是一个挑战。在这篇综述中，作者概述了癌症的表观遗传和遗传改变，组织库以及一些有希望的生物标志物或候选物，这些标志物或候选物可能最终被证明在临床上对HNC患者有益。

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