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TearLab? Osmolarity System for diagnosing dry eye

机译：TearLab？渗透压诊断眼干

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摘要

Dry eye (DE) disease is an impairment of the lachrymal unit function and one the most frequent eye problems. A major challenge is to find accurate diagnostic criteria to be able to define DE severity, as symptoms poorly correlate with clinical signs. Tear osmolarity is considered a key factor in DE onset and perpetuation; its measurement is now possible in clinical setting by an innovative electrical impedance-based lab-on-a-chip technology. This article outlines the features of DE disease and the limitations of current clinical tests. The role of tear osmolarity in DE etiopathogenesis is surveyed, and the pitfalls in measurement are discussed. Diagnostic performance, accuracy and clinical applications of the technology in focus are critically reviewed. The instrument offers the possibility to measure tear osmolarity in a rapid and reliable way in daily practice. As scientific evidence grows, it is expected in the future that it will represent an objective indicator of ocular surface health in the management of DE disease and in clinical trials.
机译：干眼（DE）病是泪单位功能的损害，是最常见的眼病之一。一个主要的挑战是要找到准确的诊断标准来定义DE的严重程度，因为症状与临床体征之间的关联性很差。渗透压被认为是DE发病和永存的关键因素。现在，通过基于电阻抗的创新型芯片实验室技术，可以在临床环境中进行测量。本文概述了DE疾病的特征和当前临床测试的局限性。泪渗透压的作用在DE病因中进行了调查，并讨论了在测量中的陷阱。严格审查了该技术的诊断性能，准确性和临床应用。该仪器在日常实践中提供了以快速可靠的方式测量泪液渗透压的可能性。随着科学证据的增长，将来有望在DE疾病的治疗和临床试验中代表眼表健康的客观指标。

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