...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental and therapeutic medicine >Anti-inflammatory activity of Yanshu spraying agent in animal models
【24h】

Anti-inflammatory activity of Yanshu spraying agent in animal models

机译：燕舒喷雾剂在动物模型中的抗炎活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute pharyngitis is characterized by an inflammation of the mucous membranes in the pharynx. Yanshu spraying agent was prepared according to the traditional Chinese formulation for the treatment of acute pharyngitis. The present study aimed to investigate the anti-inflammatory effect of Yanshu in xylene-induced ear edema in mice and carrageenan-induced paw edema in rats by measuring the degree of edema in the animal models. The histopathology and the levels of prostaglandin E2 (PGE2) and cycloxygenase-2 (COX-2) in the hind paws of the carrageenan-treated rats were also analyzed. The results showed that Yanshu significantly reduced ear edema in the mice and paw edema in the rats. Furthermore, treatment with Yanshu also reduced the number of inflammatory cells in tissue and decreased the production of PGE2 and COX-2. These results suggest that Yanshu possesses potent anti-inflammatory activity mediated by the inhibition of COX-2 expression which, in turn, downregulates the inflammatory mediator PGE2.
机译：急性咽炎的特征是咽部粘膜发炎。按照中药配方制备了燕舒喷雾剂，用于治疗急性咽炎。本研究旨在通过测量动物模型中的水肿程度来研究延舒对二甲苯引起的小鼠耳部水肿和角叉菜胶引起的大鼠爪水肿的抗炎作用。还分析了角叉菜胶治疗大鼠后爪的组织病理学和前列腺素E2（PGE2）和环氧合酶-2（COX-2）的水平。结果表明，盐鼠能明显减轻小鼠耳部水肿和大鼠爪水肿。此外，用盐舒治疗还减少了组织中炎性细胞的数量，并减少了PGE2和COX-2的产生。这些结果表明，Yanshu具有抑制COX-2表达所介导的强效抗炎活性，进而抑制了炎性介质PGE2的表达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号