...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental and therapeutic medicine >Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis
【24h】

Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis

机译：雷公藤多甙Hook F对急性坏死性胰腺炎大鼠肠道屏障功能障碍的治疗作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the current study was to investigate the therapeutic effect of Tripterygium wilfordii Hook F multiglycosides (TWG) on gut barrier dysfunction in rats with acute necrotizing pancreatitis (ANP). ANP was induced in rats using 3.5% sodium taurocholate. The rats were divided into 3 groups: the sham operation (SO), ANP and ANP+TWG groups. Biochemical and pathological change of pancreatic tissue and ileal mucosa, bacterial cultures and the survival rate were measured following surgery and treatment. TWG treatment significantly decreased amylase and lipase activities and plasma endotoxin and D-lactate levels. Edema and inflammation in the pancreas and ileal mucosa were alleviated. Positive bacterial cultures were significantly reduced. The survival rate of the rats in the ANP+TWG group was higher than that of the rats in the ANP group. TWG treatment showed beneficial effects by protecting the pancreas from bacterial infection caused by gut barrier dysfunction and improving the outcomes of the rats with ANP.
机译：本研究的目的是研究雷公藤多甙糖苷（TWG）对急性坏死性胰腺炎（ANP）大鼠肠道屏障功能障碍的治疗作用。使用3.5％牛磺胆酸钠在大鼠中诱发ANP。将大鼠分为3组：假手术（SO），ANP和ANP + TWG组。在手术和治疗后，测量胰腺组织和回肠粘膜的生化和病理变化，细菌培养物和存活率。 TWG处理显着降低了淀粉酶和脂肪酶活性以及血浆内毒素和D-乳酸水平。胰腺和回肠粘膜的水肿和炎症得到缓解。阳性细菌培养物明显减少。 ANP + TWG组大鼠的生存率高于ANP组大鼠。 TWG治疗通过保护胰腺免受肠屏障功能障碍引起的细菌感染并改善ANP大鼠的结局而显示出有益的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号