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首页> 外文期刊>Experimental and therapeutic medicine >High c-MET expression is frequent but not associated with early PSA recurrence in prostate cancer
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High c-MET expression is frequent but not associated with early PSA recurrence in prostate cancer

机译：c-MET高表达是常见的，但与前列腺癌的PSA早期复发无关

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摘要

c-MET is considered a possible therapeutic target in numerous tumor types and is also a candidate regulator of response to anti-HER2 and anti-epidermal growth factor receptor (EGFR) therapy. The aim of this study was to determine the prevalence and clinical significance of c-MET expression in hormone-naive prostate cancers. A pre-existing prostate tissue microarray (TMA) containing samples of 4,177 patients treated by radical prostatectomy was used. A total of 3,378 different prostate cancers were successfully analyzed for c-MET expression by immunohistochemistry and follow-up data were available for 4,104 patients. Membranous c-M ET immunostaining was performed for 2,655 (78.6%) tumors. High c-MET protein expression was significantly associated with a high Gleason grade (P=0.0018). However, c-MET was not a prognostic marker for biochemical recurrence. c-MET levels were also not associated with other parameters, including tumor stage, nodal stage and surgical margin status. The c-M ET protein is often overexpressed in prostate cancer, but has no prognostic relevance. However, the frequent presence of high levels of membranous c-MET protein in prostate cancer cells makes c-MET an attractive target for imaging and treatment.
机译：c-MET被认为是许多肿瘤类型中可能的治疗靶标，并且还是抗HER2和抗表皮生长因子受体（EGFR）治疗反应的候选调节剂。这项研究的目的是确定未使用激素的前列腺癌中c-MET表达的普遍性和临床意义。使用预先存在的前列腺组织微阵列（TMA），其中包含4177例接受根治性前列腺切除术治疗的患者的样本。通过免疫组织化学法成功地分析了总计3,378种不同的前列腺癌的c-MET表达，并获得了4,104位患者的随访数据。对2,655（78.6％）个肿瘤进行了膜c-M ET免疫染色。高c-MET蛋白表达与高格里森等级显着相关（P = 0.0018）。然而，c-MET不是生化复发的预后标志物。 c-MET水平也与其他参数无关，包括肿瘤分期，淋巴结分期和手术切缘状态。 c-M ET蛋白通常在前列腺癌中过表达，但与预后无关。然而，前列腺癌细胞中频繁存在的高水平膜状c-MET蛋白使c-MET成为成像和治疗的有吸引力的靶标。

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