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首页> 外文期刊>Experimental Brain Research >Ventromedial prefrontal cortex activity and rapid eye movement sleep are associated with subsequent fear expression in human subjects
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Ventromedial prefrontal cortex activity and rapid eye movement sleep are associated with subsequent fear expression in human subjects

机译：在受试者中，前内侧前额叶皮层活动和快速眼动睡眠与随后的恐惧表达有关

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In humans, activity patterns in the ventromedial prefrontal cortex (vmPFC) have been found to be predictive of subsequent fear memory consolidation. Pioneering work in rodents has further shown that vmPFC-amygdala theta synchronization is correlated with fear memory consolidation. We aimed to evaluate whether vmPFC activity during fear conditioning is (1) correlated with fear expression the subsequent day and whether (2) this relationship is mediated by rapid eye movement (REM) sleep. We analyzed data from 17 young healthy subjects undergoing a fear conditioning task, followed by a fear extinction task 24 h later, both recorded with simultaneous skin conductance response (SCR) and functional magnetic resonance imaging measurements, with a polysomnographically recorded night sleep in between. Our results showed a correlation between vmPFC activity during fear conditioning and subsequent REM sleep amount, as well as between REM sleep amount and SCR to the conditioned stimulus 24 h later. Moreover, we observed a significant correlation between vmPFC activity during fear conditioning and SCR responses during extinction, which was no longer significant after controlling for REM sleep amount. vmPFC activity during fear conditioning was further correlated with sleep latency. Interestingly, hippocampus activity during fear conditioning was correlated with stage 2 and stage 4 sleep amount. Our results provide preliminary evidence that the relationship between REM sleep and fear conditioning and extinction observed in rodents can be modeled in healthy human subjects, highlighting an interrelated set of potentially relevant trait markers.
机译：在人类中，腹侧前额叶皮层（vmPFC）中的活动模式已发现可预测随后的恐惧记忆巩固。啮齿动物的开拓性工作进一步表明，vmPFC-杏仁核theta同步与恐惧记忆巩固相关。我们旨在评估恐惧条件调节期间vmPFC的活动是否（1）与第二天的恐惧表达相关，以及（2）这种关系是否由快速眼动（REM）睡眠介导。我们分析了来自17位年轻健康受试者的数据，这些受试者正在接受恐惧条件调整任务，然后在24小时后进行恐惧消灭任务，两者均同时进行了皮肤电导反应（SCR）和功能磁共振成像测量，并在多导睡眠图记录的夜间睡眠之间进行了记录。我们的结果表明，恐惧调节期间的vmPFC活性与随后的REM睡眠量之间存在相关性，以及24小时后针对条件刺激的REM睡眠量与SCR之间存在相关性。此外，我们观察到恐惧调节过程中vmPFC活性与灭绝过程中SCR反应之间存在显着相关性，在控制REM睡眠量后，该相关性不再显着。恐惧调节期间的vmPFC活动与睡眠潜伏期进一步相关。有趣的是，恐惧调节期间的海马活动与第二阶段和第四阶段的睡眠量相关。我们的结果提供了初步的证据，即可以在健康的人类受试者中对在啮齿动物中观察到的REM睡眠与恐惧条件和灭绝之间的关系进行建模，强调了一组潜在相关的性状标记物的相互关联。

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