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首页> 外文期刊>Experimental Neurology >Wireless peripheral nerve stimulation increases pain threshold in two neuropathic rat models
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Wireless peripheral nerve stimulation increases pain threshold in two neuropathic rat models

机译：无线周围神经刺激增加了两种神经病大鼠模型的疼痛阈值

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摘要

Neurostimulation approaches including spinal cord and peripheral nerve stimulation are typically used to treat intractable chronic pain in individuals who are refractory to pain medications. Our earlier studies have shown that a voltage controlled capacitive discharge (VCCD) method of stimulation of nerve activation is able to selectively recruit activity in large myelinated nerve fibers. In this study, we were able to wirelessly activate the sciatic nerve using the VCCD waveform. The purpose of this study was to determine whether this waveform can effectively improve two of the most troublesome pain symptoms experienced by patients with chronic neuropathic pain mechanical and cold hyperalgesia. Neuropathic mechanical hyperalgesia was reproduced using the Spinal Nerve Ligation (SNL) rat model whereas cold allodynia was reproduced using the Chronic Constriction Injury (CCI) model in male rats. Von Frey and cold plate tests were used to evaluate paw withdrawal threshold and latency to withdrawal before and after stimulation in experimental and control rats. Paw withdrawal threshold increased significantly compared to post-lesion baseline after VCCD stimulation in SNL rats. We also observed a significant improvement in cold allodynia in the active implant CCI rats after stimulation. These results suggest that the VCCD stimulation using a wireless microstimulator may be effective in the treatment of neuropathic pain.
机译：包括脊髓和周围神经刺激在内的神经刺激方法通常用于治疗难治性疼痛患者的顽固性慢性疼痛。我们较早的研究表明，压敏电容放电（VCCD）刺激神经激活的方法能够选择性地募集大型有髓神经纤维的活性。在这项研究中，我们能够使用VCCD波形无线激活坐骨神经。这项研究的目的是确定这种波形是否可以有效改善慢性神经性疼痛机械性和冷痛觉过敏患者经历的两种最麻烦的疼痛症状。使用脊髓神经结扎（SNL）大鼠模型可再现神经性机械性痛觉过敏，而使用雄性大鼠的慢性收缩性损伤（CCI）模型可再现冷痛觉异常。使用冯·弗雷（Von Frey）和冷板试验评估实验性和对照大鼠刺激前后的爪退缩阈值和退缩潜伏期。在SNL大鼠中，VCCD刺激后，与病变后基线相比，足爪退缩阈值显着增加。我们还观察到刺激后，活动植入物CCI大鼠的冷异常性疼痛明显改善。这些结果表明，使用无线微刺激器进行VCCD刺激可能有效治疗神经性疼痛。

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