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首页> 外文期刊>Burns: Including Thermal Injury >Artificial dermal templates: A comparative study of NovoSorb (TM) Biodegradable Temporising Matrix (BTM) and Integra (R) Dermal Regeneration Template (DRT)
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Artificial dermal templates: A comparative study of NovoSorb (TM) Biodegradable Temporising Matrix (BTM) and Integra (R) Dermal Regeneration Template (DRT)

机译:人造皮肤模板:NovoSorb(TM)可生物降解的调温基质(BTM)和Integra(R)皮肤再生模板(DRT)的比较研究

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摘要

Background: Artificial dermal templates play an important role in physiologic wound closure after injury. In addition to contributing to stable, durable and flexible wound closure, they provide a scaffold for tissue repair. Several dermal templates are commercially available, with animal-derived Integra (R) dermal regeneration template perhaps the most widely used. NovoSorb (TM) Biodegradable Temporising Matrix (BTM) is a fully synthetic alternative that eliminates any risk of cross-species residual antigenicity. In this study, we aimed to compare early response after application of NovoSorb (TM) BTM with Integra (R) in terms of temporary wound closure, host cell infiltration, neovascularisation and collagen deposition in a mouse model.
机译:背景:人造皮肤模板在损伤后的生理性伤口闭合中起着重要作用。除了有助于稳定,持久和灵活的伤口闭合外,它们还提供了用于组织修复的支架。几种真皮模板是可商购的,其中动物衍生的Integra(R)真皮再生模板可能是使用最广泛的模板。 NovoSorb(TM)可生物降解的调温基质(BTM)是一种完全合成的替代品,可消除跨物种残留抗原性的任何风险。在这项研究中,我们旨在比较NovoSorb(TM)BTM与Integra(R)的应用后在小鼠模型中临时伤口闭合,宿主细胞浸润,新血管形成和胶原沉积方面的早期反应。

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