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首页> 外文期刊>Expert opinion on pharmacotherapy >Tapentadol for acute and chronic pain.
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Tapentadol for acute and chronic pain.

机译：他喷他多用于急性和慢性疼痛。

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Acute pain results from most surgical and procedural hospital experiences. While treatment options include nonsteroidals and local anesthetic blocks, immediate-release opioids remain the primary treatment approach for most patients. Chronic opioid therapy has also been advocated for a subset of patients with chronic nonma-lignant pain [i]. Although long-term clinical trials are needed to better define patient selection and risk stratification, a recent expert panel concluded that chronic opioid therapy could be an effective management option for carefully selected patients with chronic pain [2]. The use of immediate- and extended-release opioids for the treatment of acute, chronic and cancer pain has been limited by side effects and, in certain patients, inefficacy issues [3]. Thus, the search for universally effective opioid analgesics without limitations from side effects, tolerance, hyperalgesia, addiction or abuse potential continues to be the holy grail of opioid pharmacotherapy. This journal issue presents a clinical trial on the use of a new analgesic, tapentadol, that may have a reduced side-effect profile compared with other traditional opioid analgesics [4]
机译：急性疼痛是由大多数外科和程序性医院经验引起的。尽管治疗选择包括非甾体和局部麻醉药，但速释阿片类药物仍然是大多数患者的主要治疗方法。长期阿片类药物治疗也被提倡用于部分慢性非严重疼痛患者[i]。尽管需要长期的临床试验来更好地确定患者的选择和风险分层，但最近的一个专家小组得出结论，对于精心选择的慢性疼痛患者，慢性阿片类药物治疗可能是一种有效的治疗选择[2]。立即释放和延长释放的阿片类药物在治疗急性，慢性和癌症疼痛中的使用受到副作用以及某些患者无效的问题的限制[3]。因此，寻求不受副作用，耐受性，痛觉过敏，成瘾或滥用潜力限制的普遍有效的阿片类镇痛药仍然是阿片类药物治疗的圣杯。本期杂志介绍了使用新型镇痛药他喷他多的临床试验，与其他传统的阿片类镇痛药相比，这种药物的副作用较小[4]。

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