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首页> 外文期刊>Expert opinion on therapeutic targets >Therapeutic targets for new therapy for corticosteroid refractory asthma.
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Therapeutic targets for new therapy for corticosteroid refractory asthma.

机译：皮质类固醇难治性哮喘新疗法的治疗目标。

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BACKGROUND: Corticosteroids are the most potent anti-inflammatory agents for the treatment of mild to moderate asthma. However, a small percentage of the asthma population (< 10%) do not respond well, or at all, to corticosteroid therapy, and this severe corticosteroid-refractory asthma contributes to more than 50% of health care expenditure for all asthma because these is no appropriate pharmacological therapy. METHODS: If the molecular mechanism of corticosteroid insensitivity is uncovered, it may in turn provide insights into the key mechanism of corticosteroid action and rational implementation of treatment regimens that restore corticosteroid sensitivity or replace corticosteroid therapy. This review focuses on why severe asthma patients are corticosteroid-insensitive, and discusses present and future therapeutic and preventative strategies for corticosteroid-refractory asthma. CONCLUSIONS: Corticosteroid-refractory asthma is a heterogeneous disease and can be controlled by add-on treatment of corticosteroid-sparing agents or effective new drugs based on individual abnormalities. The elucidation of the cause of the relative lack of corticosteroid response in this subgroup of asthmatic individuals may have important implications for other diseases.
机译：背景：皮质类固醇是治疗轻度至中度哮喘最有效的消炎药。但是，一小部分哮喘患者（<10％）对皮质类固醇激素治疗反应不佳或根本没有反应，而这种严重的皮质类固醇难治性哮喘占所有哮喘病医疗保健支出的50％以上，因为没有适当的药理治疗。方法：如果未发现皮质类固醇敏感性的分子机制，则可能反过来提供对皮质类固醇作用的关键机制的见解，以及合理实施恢复皮质类固醇敏感性或替代皮质类固醇疗法的治疗方案的见解。这篇综述着重于为什么重度哮喘患者对皮质类固醇不敏感，并讨论了目前和未来皮质类固醇难治性哮喘的治疗和预防策略。结论：皮质类固醇难治性哮喘是一种异质性疾病，可以通过单独治疗皮质类固醇保持剂或有效的新药（根据个体异常）来控制。阐明这一哮喘个体亚群中相对缺乏皮质类固醇反应的原因可能对其他疾病具有重要意义。

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