Comment on: Targeting homologous recombination-mediated DNA repair in cancer

FiumeL.

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Comment on: Targeting homologous recombination-mediated DNA repair in cancer

机译：评论：针对癌症的同源重组介导的DNA修复

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In the April issue of 'Expert Opinion on Therapeutic Targets', Carvalho and Kanaar reviewed researches aimed at increasing the anticancer activity of genotoxic drugs by association with small molecules able to hinder DNA repair. As stressed by Li , a caveat of this interesting approach is the potential for secondary malignancies that might emerge after successful control of the primary cancer.

机译：在4月的“治疗目标专家意见”中，Carvalho和Kanaar审查了旨在通过与能够阻碍DNA修复的小分子结合来提高遗传毒性药物的抗癌活性的研究。正如Li所强调的，这种有趣方法的一个警告是成功控制原发癌后可能会出现继发性恶性肿瘤。

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《Expert opinion on therapeutic targets》 |2014年第7期|共1页
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FiumeL.;
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1. Comment on: Targeting homologous recombination-mediated DNA repair in cancer [J] . FiumeL. Expert opinion on therapeutic targets . 2014,第7期

机译：评论：针对癌症的同源重组介导的DNA修复
2. BET proteins regulate homologous recombination-mediated DNA repair: BRCAness and implications for cancer therapy [J] . Mio Catia, Gerratana Lorenzo, Bolis Marco, International Journal of Cancer =: Journal International du Cancer . 2019,第4期

机译：BET蛋白调节同源重组介导的DNA修复：BRCANESS和对癌症治疗的影响
3. Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer [J] . KonstantinopoulosP.A., WilsonA.J., SaskowskiJ., Gynecologic Oncology: An International Journal . 2014,第3期

机译：Suberoylanilide异羟肟酸（SAHA）通过靶向卵巢癌中的同源重组DNA修复增强olaparib的活性
4. Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway [C] . Nigel C. Brissett, Aidan J. Doherty Biochemical Society Symposium . 2009

机译：通过原核非同源终端连接途径修复DNA双链断裂
5. A group of homologous DNA replication origins and replicators dispersed throughout the human genome & Anticancer compounds targeting DNA replication initiation proteins from Chinese medicinal herbals. [D] . Wang, Ziyi. 2010

机译：一组同源的DNA复制起点和复制子，分布在整个人类基因组中，并且具有针对中草药DNA复制起始蛋白的抗癌化合物。
6. Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance [O] . Lei Liu, Yuanyuan Chen, Yijuan Huang, 2021

机译：长期非编码RNA anril通过维持ATR蛋白稳定性来提高癌症抗性来促进同源重组介导的DNA修复
7. BET proteins regulate homologous recombination-mediated DNA repair: BRCAness and implications for cancer therapy [O] . Catia Mio, Lorenzo Gerratana, Marco Bolis, 2018

机译：BET蛋白调节同源重组介导的DNA修复：BRCANESS和对癌症治疗的影响

Comment on: Targeting homologous recombination-mediated DNA repair in cancer

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