The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies

Perez-Verdaguer Mireia; Capera Jesusa; Serrano-Novillo Clara; Estadella Irene; Sastre Daniel; Felipe Antonio

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The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies

机译：电压门控钾通道Kv1.3是针对人类疾病的有前途的多种治疗靶标

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Introduction: The voltage-dependent potassium channel Kv1.3 is mainly present in the nervous and immune systems. In leukocytes, Kv1.3 fine-tunes the activation and proliferation of the immune response. However, Kv1.3 is also present in other tissues where its physiological role is still under investigation. Thus, Kv1.3 alterations have been related to several human diseases.

机译：简介：电压依赖性钾通道Kv1.3主要存在于神经和免疫系统中。在白细胞中，Kv1.3可微调免疫反应的激活和增殖。但是，Kv1.3也存在于其他组织中，其生理作用仍在研究中。因此，Kv1.3的改变与几种人类疾病有关。

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《Expert opinion on therapeutic targets》 |2016年第5期|共15页
作者
Perez-Verdaguer Mireia; Capera Jesusa; Serrano-Novillo Clara; Estadella Irene; Sastre Daniel; Felipe Antonio;
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正文语种 eng
中图分类药学;
关键词
inflammatory disorders; clinical trials; Autoimmune diseases; obesity; cancer; Kv1.3 blockers;

机译：炎性疾病;临床试验;自身免疫性疾病;肥胖症;癌症;Kv1.3阻滞剂;

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1. The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies [J] . Perez-Verdaguer Mireia, Capera Jesusa, Serrano-Novillo Clara, Expert opinion on therapeutic targets . 2016,第5期

机译：电压门控钾通道Kv1.3是针对人类疾病的有前途的多种治疗靶标
2. The influence of 8-prenylnaringenin on the activity of voltage-gated kv1.3 potassium channels in human jurkat t cells [J] . Andrzej Teisseyre, Anna Uryga, Justyna G#261, Cellular & molecular biology letters. . 2012,第4期

机译：8-异戊烯基柚皮苷对人Jurkat T细胞电压门控的kv1.3钾通道活性的影响
3. Influence of Specific Immunotherapy on the Activity of Human T Lymphocyte Kv1.3 Voltage-Gated Potassium Channels in Insect Venom Allergic Patients [J] . Marita Nittner-Marszalska, Andrzej Teisseyre, Bożena Jaźwiec, The Journal of Membrane Biology . 2011,第1期

机译：昆虫免疫过敏患者特异性免疫疗法对人T淋巴细胞Kv1.3电压门控钾通道活性的影响
4. Recombinant Fluorescent Ligand of Potassium Kv1.1 and Kv1.3 Channels: Design, Properties and Applications [C] . Alexey V. Feofanov, Kseniya S. Kudryashova, Anastasiya A. Ignatova, International Multidisciplinary Microscopy and Microanalysis Congress . 2017

机译：钾钾的重组荧光配体和KV1.3通道：设计，性能和应用
5. The Roles of KCNQ1 (Potassium Voltage-Gated Channel, KQT-like Subfamily, Member 1) and CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) in Mouse and Human GI Cancers. [D] . Than, Bich Le Ngoc. 2013

机译：KCNQ1（钾电压门控通道，KQT样亚家族，成员1）和CFTR（囊性纤维化跨膜电导调节剂）在小鼠和人类胃肠癌中的作用。
6. The influence of 8-prenylnaringenin on the activity of voltage-gated kv1.3 potassium channels in human jurkat t cells [O] . Justyna Gąsiorowska, Andrzej Teisseyre, Anna Uryga, 2012

机译：8-异戊烯基柚皮苷对人Jurkat T细胞电压门控的kv1.3钾通道活性的影响
7. The influence of 8-prenylnaringenin on the activity of voltage-gated kv1.3 potassium channels in human jurkat t cells [O] . Justyna Gąsiorowska, Andrzej Teisseyre, Anna Uryga, 2012

机译：8-戊酮蛋白对人Jurkat T细胞电压门控KV1.3钾通道活性的影响

The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies

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