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首页> 外文期刊>Expert opinion on therapeutic targets >Osteopontin as a therapeutic target for cancer
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Osteopontin as a therapeutic target for cancer

机译：骨桥蛋白作为癌症的治疗靶标

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Introduction: Cancer is a complex pathological disorder, established as a result of accumulation of genetic and epigenetic changes, which lead to adverse alterations in the cellular phenotype. Tumor progression involves intricate signaling mediated through crosstalk between various growth factors, cytokines and chemokines. Osteopontin (OPN), a chemokine-like protein, is involved in promotion of neoplastic cancer into higher grade malignancies by regulating various facets of tumor progression such as cell proliferation, angiogenesis and metastasis.Areas covered: Tumors as well as stroma-derived OPN play key roles in various signaling pathways involved in tumor growth, angiogenesis and metastasis. OPN derived from tumor-activated macrophages modulates the tumor microenvironment and thereby regulate melanoma growth and angiogenesis. OPN also regulates hypoxia-inducible factor-1α-dependent VEGF expression leading to breast tumor growth and angiogenesis in response to hypoxia. Thus, a clear understanding of the molecular mechanism underlying OPN-mediated regulation will shed light on exciting avenues for further investigation of targeted therapies. Silencing of OPN using RNAi technology, blocking OPN activity using specific antibodies and small-molecule inhibitors might provide novel strategies, which would aid in developing effective therapeutics for the treatment of various types of cancer.Expert opinion: This review focuses on new possibilities to exploit OPN as a tumor and stroma-derived therapeutic target to combat cancer.
机译：简介：癌症是一种复杂的病理性疾病，是由于遗传和表观遗传学变化的积累而建立的，导致细胞表型发生不利变化。肿瘤进展涉及各种生长因子，细胞因子和趋化因子之间的串扰介导的复杂信号传导。骨桥蛋白（OPN）是一种趋化因子样蛋白，通过调节肿瘤进展的各个方面（如细胞增殖，血管生成和转移），参与将肿瘤转变为恶性肿瘤，涉及的领域：肿瘤以及源自基质的OPN发挥作用在涉及肿瘤生长，血管生成和转移的各种信号通路中的关键作用。源自肿瘤活化巨噬细胞的OPN调节肿瘤微环境，从而调节黑色素瘤的生长和血管生成。 OPN还调节缺氧诱导因子1α依赖性VEGF的表达，从而导致乳腺肿瘤生长和对缺氧的血管生成。因此，对OPN介导的调控的分子机制的清晰理解将为进一步研究靶向疗法提供令人兴奋的途径。使用RNAi技术沉默OPN，使用特异性抗体和小分子抑制剂阻断OPN活性可能提供新颖的策略，这将有助于开发有效的疗法来治疗各种类型的癌症。 OPN作为抗癌的肿瘤和基质来源的治疗靶标。

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