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首页> 外文期刊>Expert opinion on therapeutic targets >Effect of bacterial and host factors on Helicobacter pylori eradication therapy
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Effect of bacterial and host factors on Helicobacter pylori eradication therapy

机译：细菌和宿主因素对幽门螺杆菌根除治疗的影响

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Introduction: A clearer understanding of the factors affecting the cure rate of Helicobacter pylori infection might lead to the development of novel prevention strategies and therapeutic targets.Areas covered: This review covers two important issues that affect the eradication of H. pylori: bacterial and host factors. Several virulence factors have been shown to be predictors for gastroduodenal diseases. Successful treatment of H. pylori infection also depends on host genetic factors such as CYP2C19 and IL-1B. The latest evidence on host genetic factors is discussed.Expert opinion: The authors identify three main targets for achieving effective eradication therapy. The first therapeutic target is to identify counter measures for antibiotic-resistant H. pylori strains. Thus, antibiotic susceptibility should be checked in all patients, ideally, before the start of eradication treatment. The second therapeutic target is the inhibition of acid suppression. Maintaining a high intragastric pH for 24 h increases the effectiveness of some antibiotics and the eradication effects for H. pylori. The third therapeutic target is to identify high-risk groups; the CYP2C19 and IL-1B polymorphisms are candidates for significant risk factors. A personalized medical approach will likely increase the cure rate of H. pylori infection.
机译：简介：对影响幽门螺杆菌感染治愈率的因素的更清晰的了解可能会导致新的预防策略和治疗靶标的发展。涵盖的领域：本综述涵盖影响幽门螺杆菌根除的两个重要问题：细菌和宿主因素。几种毒力因子已被证明是胃十二指肠疾病的预测因子。幽门螺杆菌感染的成功治疗还取决于宿主遗传因素，例如CYP2C19和IL-1B。讨论了宿主遗传因素的最新证据。专家意见：作者确定了实现有效根除治疗的三个主要目标。第一个治疗目标是确定针对抗生素耐药的幽门螺杆菌菌株的对策。因此，最好在开始根除治疗之前检查所有患者的抗生素敏感性。第二个治疗目标是抑制酸抑制。维持胃内高pH 24小时可提高某些抗生素的效力，并消除幽门螺杆菌。第三个治疗目标是确定高危人群。 CYP2C19和IL-1B多态性是重要危险因素的候选者。个性化的医疗方法可能会提高幽门螺杆菌感染的治愈率。

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