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Targeting AAC-11 in cancer therapy.

机译：在癌症治疗中靶向AAC-11。

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IMPORTANCE OF THE FIELD: Since its discovery in 1997, the antiapoptotic factor AAC-11 has rapidly gained attention due to its potential use in cancer therapy. Indeed, most cancer cells express elevated levels of AAC-11, which is now known to be involved in both tumor cells growth as well as sensitivity to chemotherapeutic drugs. AREAS COVERED IN THIS REVIEW: In this review, we examine the most recent evidence about the role of AAC-11 in cancer biology and the therapeutic perspectives associated with its specific targeting. For that purpose, literature dealing with AAC-11 in the PubMed database was reviewed from 1997 up to date. WHAT THE READER WILL GAIN: AAC-11 is an antiapoptotic gene that has the potential to be a target for anti-cancer therapy, and warrants further investigation. As its expression seems to predict unfavorable prognosis, at least in some cancers, it also may become a potent prognostic marker. TAKE HOME MESSAGE: Blocking AAC-11 function in cancer for therapeutic purposes might be of great interest. The recent report of efficient AAC-11 inhibiting peptides that sensitize tumor cells to chemotherapeutic drugs has raise the exciting notion that AAC-11 might be a druggable target and fueled the search for new therapeutic agents that could block AAC-11 function.
机译：领域的重要性：自1997年发现以来，抗凋亡因子AAC-11因其在癌症治疗中的潜在用途而迅速受到关注。确实，大多数癌细胞表达的AAC-11水平升高，现在已知这既参与肿瘤细胞的生长，又对化学治疗药物敏感。该评价涵盖的领域：在本评价中，我们研究了有关AAC-11在癌症生物学中的作用以及与其特异性靶向相关的治疗观点的最新证据。为此，从1997年至今，对PubMed数据库中有关AAC-11的文献进行了回顾。读者所能获得的知识：AAC-11是一种抗凋亡基因，具有成为抗癌治疗靶标的潜力，值得进一步研究。由于其表达似乎预示着不良的预后，至少在某些癌症中，它也可能成为有效的预后标志物。温馨提示：出于治疗目的，阻断AAC-11在癌症中的功能可能引起人们的极大兴趣。最近关于使肿瘤细胞对化疗药物敏感的有效AAC-11抑制肽的报告提出了令人兴奋的观念，即AAC-11可能是可药物治疗的靶标，并推动了寻找可以阻断AAC-11功能的新治疗剂的探索。

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