• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on therapeutic targets >Targeting the fetal acetylcholine receptor in rhabdomyosarcoma
【24h】

Targeting the fetal acetylcholine receptor in rhabdomyosarcoma

机译：针对横纹肌肉瘤中的胎儿乙酰胆碱受体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Recent efforts to enhance overall survival of patients with clinically advanced RMS have failed and there is a demand for conceptually novel treatments. Immune therapeutic options targeting the fetal nicotinic acetylcholine receptor (fnAChR), which is broadly expressed on RMS, are novel approaches to overcome the therapeutic resistance of RMS. Expression of the fnAChR is restricted to developing fetal muscles, some apparently dispensable ocular muscle fibers and thymic myoid cells. Therefore, after-birth fnAChR is a tumor-associated and almost tumor-specific antigen on RMS cells. Areas covered: This review gives an overview on nAChR function and expression pattern in RMS tumor cells, and deals with the immunological significance of fnAChR-expressing cells, including the risk of anti-nAChR autoimmunity as a potential side effect of fnAChR-directed immunotherapies. The article also addresses the advantages and disadvantages of vaccination strategies, immunotoxins and chimeric T cells targeting the fnAChR. Expert opinion: Finally, we suggest technical and biological strategies to improve the available immunotherapeutic tools including increasing the in vivo expression of the target fnAChR on RMS cells.
机译：简介：横纹肌肉瘤（RMS）是儿童和青春期最常见的软组织肉瘤。最近为增强临床上晚期RMS患者的整体生存所做的努力失败了，因此需要概念上新颖的治疗方法。针对RMS广泛表达的针对胎儿烟碱乙酰胆碱受体（fnAChR）的免疫治疗选择是克服RMS治疗耐药性的新方法。 fnAChR的表达仅限于发育中的胎儿肌肉，一些明显不需要的眼肌纤维和胸腺肌样细胞。因此，产后fnAChR是RMS细胞上与肿瘤相关且几乎是肿瘤特异性的抗原。涵盖的领域：本综述概述了RMS肿瘤细胞中nAChR的功能和表达模式，并探讨了表达fnAChR的细胞的免疫学意义，包括抗nAChR自身免疫的风险，这是fnAChR定向免疫疗法的潜在副作用。本文还讨论了针对fnAChR的疫苗接种策略，免疫毒素和嵌合T细胞的优缺点。专家意见：最后，我们建议技术和生物学策略以改善可用的免疫治疗工具，包括增加RMS细胞上目标fnAChR的体内表达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号