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首页> 外文期刊>Expert opinion on therapeutic targets >Targeting DSG3: From pemphigus to squamous cell carcinoma
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Targeting DSG3: From pemphigus to squamous cell carcinoma

机译：靶向DSG3：从天疱疮到鳞状细胞癌

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Desmosomes are specialized structures of the cell membrane that are crucial for the establishment and maintenance of cell-cell adhesion and tissue integrity. Transmembrane proteins of desmosomes, desmogleins, and desmocollins are responsible for extracellular binding and, thus, are important for interkeratinocyte cohesion. Desmoglein 3 (DSG3) is a member of the desmoglein subfamily of cadherin cell adhesion molecule superfamily. It is mainly expressed in stratified epithelia, including the basal and suprabasilar epidermal layers and throughout the oral epithelium layers. In the human autoimmune blistering disease pemphigus vulgaris, autoantibodies against DSG3 cause loss of cell-cell adhesion (acantholysis) with resultant epidermal and mucosal blisters. More recently, a potential role of desmosomes in cancer development has been hypothesized. To this regard, several investigations have focused on the possible contribution of DSG3 in carcinogenesis. In this article, the role of DSG3 in the process of squamous cell carcinogenesis and the controversies concerning this issue will be discussed.
机译：桥粒是细胞膜的特殊结构，对于建立和维持细胞粘附和组织完整性至关重要。桥粒体，桥粒芯蛋白和桥粒胶蛋白的跨膜蛋白负责细胞外结合，因此对于角质形成细胞之间的凝聚力很重要。 Desmoglein 3（DSG3）是钙粘着细胞粘附分子超家族的desmoglein亚家族的成员。它主要在分层的上皮中表达，包括基底和睑上皮表皮层以及整个口腔上皮层。在人类自身免疫性水疱性寻常性天疱疮疾病中，针对DSG3的自身抗体会导致细胞间粘附（棘皮溶解）的丧失，并导致表皮和粘膜水泡。最近，已经提出了桥粒在癌症发展中的潜在作用。为此，一些研究集中于DSG3在致癌中的可能贡献。在本文中，将讨论DSG3在鳞状细胞癌变过程中的作用以及有关此问题的争议。

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