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Targeting ubiquilin-1 in Alzheimer's disease

机译：靶向泛醇-1在阿尔茨海默氏病中

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Introduction: Alzheimer's disease (AD) is a common neurodegenerative disorder affecting an increasing number of people worldwide as the population ages. Currently, there are no drugs available that could prevent AD pathogenesis or slow down its progression. Increasing evidence links ubiquilin-1, an ubiquitin-like protein, into the pathogenic mechanisms of AD and other neurodegenerative diseases. Ubiquilin-1 has been shown to play a key role in the regulation of the levels, subcellular targeting, aggregation and degradation of various neurodegenerative disease-associated proteins. These include the amyloid precursor protein and presenilins that are intimately involved in the mechanisms of AD. Areas covered: Here, the properties and diverse functions of ubiquilin-1 protein in the context of the pathogenesis of AD and other neurodegenerative disorders are discussed. This review recapitulates the available knowledge on the involvement of ubiquilin-1 in the genetic and molecular mechanisms in AD. Furthermore, the association of ubiquilin-1 with specific proteins and mechanisms involved in the pathogenesis of neurodegenerative diseases is described and the known ubiquilin-1-interacting proteins summarized. Expert opinion: The variety of ubiquilin-1-interacting proteins and its central role in the regulation of protein levels and degradation provides a number of novel candidates and approaches for future research and drug discovery.
机译：简介：阿尔茨海默氏病（AD）是一种常见的神经退行性疾病，随着人口老龄化，影响着全球越来越多的人。目前，尚无可预防AD发病机制或减慢其进展的药物。越来越多的证据表明，泛素样蛋白ubiquilin-1与AD和其他神经退行性疾病的致病机制有关。已显示Ubiquilin-1在各种神经退行性疾病相关蛋白的水平，亚细胞靶向，聚集和降解的调节中起关键作用。这些包括淀粉样蛋白前体蛋白和早老蛋白，它们与AD的机制密切相关。涵盖的领域：在这里，讨论AD和其他神经退行性疾病的发病机制中ubiquilin-1蛋白的特性和多种功能。这篇综述概括了关于泛醇-1参与AD的遗传和分子机制的现有知识。此外，描述了泛醇-1与特定蛋白的关系以及神经退行性疾病的发病机理，并概述了已知的泛醇-1相互作用蛋白。专家意见：泛醇1相互作用蛋白的多样性及其在调节蛋白水平和降解中的核心作用为未来的研究和药物发现提供了许多新颖的候选方法。

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