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首页> 外文期刊>Expert opinion on therapeutic targets >Upregulating substance P levels to treat obstructive sleep apnea
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Upregulating substance P levels to treat obstructive sleep apnea

机译：上调P物质水平以治疗阻塞性睡眠呼吸暂停

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摘要

Background: The neuropeptide (tachykinin) substance P is widely distributed in the central and peripheral nervous systems. Substance P has been suggested to function as a neurotransmitter, cotransmitter, or neuromodulator in the central and peripheral nervous system. substance P also influences sleep physiology. Neurokinin 1 (NK-1) receptors may also be implicated in the control of sleep/wake behavior. Obstructive sleep apnea syndrome (OSAS) is defined as repeated episodes of upper airway occlusion during sleep with subsequent excessive daytime sleepiness (EDS). Subsatance P levels are found to be significantly lowered in patients with OSAS. Objective: The aim of this review was to investigate the relationship between substance P, EDS and other OSAS complications. Methods: The literature was searched using standard methods. Medline and Embase were searched systematically from 1974 to the end of February 2008 for relevant articles published in English. Results/conclusion: EDS seen in some OSAS patients may be associated with various pathophysiological mechanisms including changes in substance P levels. Intravenous substance P administration in OSAS patients can be effective in the treatment of EDS. Further studies on the possible relationship between low serum substance P and hypertension, reproductive function disorders, memory and learning problems in OSAS cases is required.
机译：背景：神经肽（速激肽）物质P广泛分布于中枢和周围神经系统。已经建议P物质在中枢神经系统和周围神经系统中充当神经递质，共递质或神经调节剂。 P物质也会影响睡眠生理。神经激肽1（NK-1）受体也可能与睡眠/苏醒行为的控制有关。阻塞性睡眠呼吸暂停综合症（OSAS）的定义是睡眠期间反复发作的上呼吸道阻塞以及随后的过度白天嗜睡（EDS）。发现OSAS患者的P物质水平显着降低。目的：本综述旨在研究P物质，EDS和其他OSAS并发症之间的关系。方法：采用标准方法检索文献。从1974年到2008年2月底，系统搜索了Medline和Embase，以英文发表了相关文章。结果/结论：在一些OSAS患者中发现的EDS可能与各种病理生理机制有关，包括P物质水平的变化。 OSAS患者静脉内施用P物质可以有效治疗EDS。需要进一步研究低血清P物质与OSAS病例中高血压，生殖功能障碍，记忆和学习问题之间的可能关系。

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