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MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy

机译：MicroRNA-323-3p在类风湿关节炎，阿尔茨海默氏病和异位妊娠中具有临床潜力

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Introduction: MicroRNAs (miRNAs) are a group of noncoding RNAs,～ 20-22 nucleotides in length, that repress target gene expression through mRNA degradation and translation inhibition. The gene encoding miR-323-3p, which is a biomarker in immune and inflammatory responses, exists in a miRNA cluster in chromosomal region 14q32.31. It has been shown that miR-323-3p associates with the pathogenesis of several diseases, such as rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy. Areas covered: This review provides a current view on the association of miR-323-3p with several human diseases and is focused on the recent studies of miR-323-3p regulation, discussing its potential as an epigenetic biomarker and therapeutic target for these diseases. In particular, the mechanisms of miR-323-3p in these diseases and how miR-323-3p is regulated are also discussed. Expert opinion: Although the exact role of miR-323-3p in these diseases has not been fully elucidated, targeting miR-323-3p may serve as a promising therapy strategy.
机译：简介：MicroRNA（miRNA）是一组非编码RNA，长度约20-22个核苷酸，可通过mRNA降解和翻译抑制来抑制靶基因的表达。编码miR-323-3p的基因是免疫和炎症反应的生物标记，存在于染色体区域14q32.31的miRNA簇中。已经表明，miR-323-3p与多种疾病的发病机理有关，例如类风湿性关节炎，阿尔茨海默氏病和异位妊娠。涵盖的领域：这篇综述提供了关于miR-323-3p与几种人类疾病的关联的最新观点，并且侧重于miR-323-3p调控的最新研究，讨论了其作为这些疾病的表观遗传标记和治疗靶标的潜力。特别是，还讨论了miR-323-3p在这些疾病中的机制以及如何调控miR-323-3p。专家意见：尽管尚未完全阐明miR-323-3p在这些疾病中的确切作用，但靶向miR-323-3p可能是一种有前途的治疗策略。

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