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Microbial pathogen genomes - new strategies for identifying therapeutic and vaccine targets.

机译：微生物病原体基因组-识别治疗和疫苗目标的新策略。

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摘要

Efficient mining of genomic sequence information from multiple pathogens for therapeutic and vaccine targets requires efficient tools. Fortunately, robust methods applicable to whole genomes have been developed and applied in the past few years to identify genes essential for growth or virulence and to detect potential vaccine targets. Successful approaches to identify potential therapeutic targets include a variety of ingenious uses of nearly random transposon insertions, more directed methods such as antisense and insertion-duplication mutagenesis, and expression profiling facilitated by microarrays. Vaccine targets have been identified by gene fusion and expression experiments to discover gene products that are immunogenic in humans or animal models. All genome-wide methods require focused secondary assays to validate the findings, but these genomic methods excel at reducing to a manageable number the genes to be examined further. This editorial reviews the latest developments in genome-wide target identification tools.
机译：有效地从多种病原体中挖掘治疗和疫苗靶标的基因组序列信息需要高效的工具。幸运的是，在过去的几年中，已经开发出了适用于整个基因组的鲁棒方法，以鉴定对生长或毒力至关重要的基因并检测潜在的疫苗靶标。识别潜在治疗靶点的成功方法包括各种巧妙的用途，包括近乎随机的转座子插入，更直接的方法，例如反义和插入重复诱变，以及微阵列促进的表达谱分析。已经通过基因融合和表达实验确定了疫苗靶标，以发现在人类或动物模型中具有免疫原性的基因产物。所有全基因组方法都需要进行集中的二级分析以验证发现，但是这些基因组方法擅长将待进一步检查的基因减少到可管理的数量。这篇社论回顾了全基因组靶标识别工具的最新发展。

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