Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes.

Barton BE

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Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes.

机译：白细胞介素6和治疗癌症，过度增殖性疾病和副肿瘤综合症的新策略。

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Interleukin-6 (IL-6) is a pleiomorphic cytokine whose growth factor properties play an important role in the development and progression of many types of cancer. IL-6 is produced in response to a variety of stimuli, and is required for the development of T and B lymphocytes to effector cells. In certain neoplasias, such as multiple myeloma, IL-6 is both produced and required for survival by the cancer cell itself. In other neoplasias, IL-6 may come from tissue surrounding the tumour. Thus, therapeutic strategies aimed at inhibiting the production, expression or action of IL-6 would be quite beneficial in the treatment of cancer. Moreover, IL-6 is a pathophysiological factor in several hyperproliferative diseases and the paraneoplastic syndromes that often accompany cancer, such as cachexia and osteoporosis; thus, anti-IL-6 therapy would be useful in treating these entities as well. This expert opinion acquaints the reader with IL-6, its physiological responses, the cancer types with which it is associated, and discusses the current state of therapy aimed at inhibiting it.

机译：白介素-6（IL-6）是一种多形细胞因子，其生长因子特性在多种类型的癌症的发生和发展中起着重要的作用。 IL-6是响应多种刺激而产生的，是T和B淋巴细胞向效应细胞发育所必需的。在某些瘤形成中，例如多发性骨髓瘤，癌细胞自身既产生IL-6又需要IL-6生存。在其他肿瘤中，IL-6可能来自肿瘤周围的组织。因此，旨在抑制IL-6的产生，表达或作用的治疗策略在癌症的治疗中将是非常有益的。此外，IL-6是多种恶性增生性疾病和恶性肿瘤常伴随癌症的病理生理因素，例如恶病质和骨质疏松症。因此，抗IL-6疗法也将在治疗这些实体中有用。该专家意见使读者熟悉IL-6，其生理反应，与之相关的癌症类型，并讨论了旨在抑制其的当前治疗状态。

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《Expert opinion on therapeutic targets》 |2005年第4期|共16页
作者
Barton BE;
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正文语种 eng
中图分类药学;
关键词
Interleukin-6; Malignant Neoplasms; Interleukin-6 Assay; therapeutic aspects; 白细胞介素6;

机译：Interleukin-6;Malignant Neoplasms;Interleukin-6 Assay;therapeutic aspects;白细胞介素6;

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机译：白细胞介素6和治疗癌症，过度增殖性疾病和副肿瘤综合症的新策略。
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机译：拟议的预防与工作有关的疾病和伤害的国家战略：职业癌症

Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes.

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