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首页> 外文期刊>Expert opinion on therapeutic targets >Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia.
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Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia.

机译：ZAP-70在慢性淋巴细胞性白血病中的功能和预后作用。

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摘要

It has become clear that the heterogeneity of chronic lymphocytic leukaemia (CLL) is not a continuous spectrum, but is bipolar. Originally distinguished by the mutational status of the immunoglobulin variable region genes, the two poles are perhaps better identified by the expression of ZAP-70, a signalling molecule normally utilised by T cells rather than B cells, but anomalously expressed in the more aggressive subtype of CLL. Assaying ZAP-70 expression has become progressively simplified so that a directly stained flow cytometric test is currently being evaluated, and a version of this should shortly be available to routine laboratories. In addition, the understanding of the nature of CLL has been advanced rapidly and this should lead to new, better targeted therapies, which in contrast to the current armoury, will work better for the more malignant variants of CLL than for the more benign. In particular, ZAP-70 is especially attractive because its aberrant expression in tumour cells from the more aggressive forms of CLL requires the chaperoning action of activated heat-shock protein 90, which may be specifically inhibited.
机译：已经清楚的是，慢性淋巴细胞性白血病（CLL）的异质性不是连续的谱，而是双相的。最初通过免疫球蛋白可变区基因的突变状态来区分，这两个极点可能通过ZAP-70的表达来更好地识别，ZAP-70是T细胞而非B细胞通常利用的信号分子，但在更具侵略性的亚型中表达CLL。 ZAP-70表达的测定已逐步简化，因此目前正在评估直接染色的流式细胞术测试，并且常规实验室不久应可使用此版本。此外，对CLL性质的理解已得到快速发展，这将导致新的，靶向性更好的疗法，与目前的军械库相比，对于CLL较恶性的变种，其良性治疗效果更好。特别地，ZAP-70尤其具有吸引力，因为它以更具攻击性的CLL形式在肿瘤细胞中异常表达需要活化的热激蛋白90的陪伴作用，而后者可能被特异性抑制。

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