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The potential of class 3 semaphorins as both targets and therapeutics in cancer

机译:3类信号量在癌症中既是靶标又是治疗剂的潜力

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Introduction: Semaphorins have been originally identified as a family of evolutionary conserved soluble or membrane-associated proteins involved in diverse developmental phenomena. This family of proteins profoundly influences numerous pathophysiological processes, including organogenesis, cardiovascular development and immune response. Apart from steering the neural networking process, these are implicated in a broad range of biological operations including regulation of tumor progression and angiogenesis.
机译:简介:Semaphorins最初被确定为涉及多种发育现象的进化保守的可溶性或膜相关蛋白家族。该蛋白家族深刻影响许多病理生理过程,包括器官发生,心血管发育和免疫反应。除了指导神经网络过程外,这些还涉及广泛的生物学操作,包括调节肿瘤的进展和血管生成。

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