NF-kappaB as a target for cancer therapy.

Melisi D; Chiao PJ

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NF-kappaB as a target for cancer therapy.

机译：NF-κB作为癌症治疗的靶标。

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NF-kappaB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the different types of inhibitors targeting the NF-kappaB pathway at several stages.

机译：NF-κB转录因子和激活它们的信号通路在癌症的发展，进展和治疗中起着至关重要的作用，最近已成为药物开发和研究工作的重点。本文对在不同阶段靶向NF-κB途径的不同类型抑制剂进行了严格的综述。

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《Expert opinion on therapeutic targets》 |2007年第2期|共12页
作者
Melisi D; Chiao PJ;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Not free of; cancer therapy; development aspects; drug discovery; activate;

机译：并非没有;癌症治疗;发展方面;药物发现;激活;

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专利

1. Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. [J] . Li F, Sethi G Biochimica et biophysica acta. Reviews on cancer . 2010,第2期

机译：在癌症治疗中靶向转录因子NF-κB以克服化学抗性和放射抗性。
2. R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy. [J] . Dey A, Wong ET, Cheok CF, Cell death and differentiation . 2008,第2期

机译：R-Roscovitine同时靶向p53和NF-kappaB途径并引起凋亡增强：在癌症治疗中具有重要意义。
3. NF-kappaB as a target for cancer therapy. [J] . Melisi D, Chiao PJ Expert opinion on therapeutic targets . 2007,第2期

机译：NF-κB作为癌症治疗的靶标。
4. Demonstration of Enhanced Targeted Delivery of Drug-Loaded Polymers with Bombesin-Bispecific Antibody Complex for Cancer Therapy. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：用Bombesin-Bispecectific抗体复合物用于癌症治疗的增强靶向递送药物含量的靶向递送的证明。
5. The role of NF-kappaB activation in stress-induced resistance of EMT6 cells to anticancer therapy. [D] . Brandes, Lori May. 2002

机译：NF-κB活化在应激诱导的EMT6细胞对抗癌治疗的抗性中的作用。
6. Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer [O] . Renata A. M. Rossetti, Ildefonso A. da Silva-Junior, Gretel R. Rodríguez, 2020

机译：本地和系统性STAT3和P65 NF-KAPPAB表达为宫颈癌患者的进展标志物和功能靶标
7. Inhibition of NF-kappaB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy. [O] . Palmer, DH, Chen, MJ, Searle, PF, 2005

机译：抑制NF-κB增强了病毒导向的酶前药治疗和溶瘤腺病毒癌基因治疗的细胞毒性。

NF-kappaB as a target for cancer therapy.

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