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14-3-3 zeta as novel molecular target for cancer therapy

机译：14-3-3 Zeta作为癌症治疗的新型分子靶标

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Introduction: 14-3-3ζ acts as a central hub in signaling networks, which promotes cell proliferation, adhesion and survival and inhibits apoptosis in multiple cancers. Development of inhibitors or agents that interfere with 14-3-3ζ-dependent signaling networks are likely to serve as novel molecular agents for targeted cancer therapy. Areas covered: The role of 14-3-3ζ in cancer and its potential as a novel molecular target for therapy. The involvement of 14-3-3ζ in chemoresistance in multiple cancers provides a rationale for developing novel molecular therapies targeting this protein for more effective cancer management. The keywords used to conduct the literature search for this paper were '14-3-3/14-3-3zeta and cancer', '14-3-3 structure', '14-3-3 inhibitors', '14-3-3 cancer prognosis', '14-3-3 and cancer therapy', 'role/ functions of 14-3-3'. Expert opinion: 14-3-3ζ is a central cellular hub protein regulating multiple signaling pathways involved in cancer development, progression and therapeutic resistance. Thus, 14-3-3ζ may serve as a novel molecular target for cancer therapy. New approaches including synthetic and/or natural inhibitors that interfere with 14-3-3ζclient interactions need to be developed for effective cancer therapy.
机译：简介：14-3-3ζ是信号网络中的中心枢纽，可促进多种癌症中的细胞增殖，粘附和存活并抑制细胞凋亡。干扰14-3-3ζ依赖性信号传导网络的抑制剂或药物的开发可能会成为靶向癌症治疗的新型分子药物。涵盖的领域：14-3-3ζ在癌症中的作用及其作为治疗新分子靶标的潜力。 14-3-3ζ参与多种癌症的化学耐药性为开发针对该蛋白质的新型分子疗法以更有效地进行癌症治疗提供了理论依据。用于进行文献检索的关键词是'14 -3-3 / 14-3-3zeta and Cancer'，'14-3-3结构'，'14 -3-3抑制剂'，'14 -3 -3癌症预后”，“ 14-3-3和癌症治疗”，“角色/功能14-3-3”。专家意见：14-3-3ζ是一种中央细胞中枢蛋白，可调节参与癌症发展，进程和治疗抗性的多种信号通路。因此，14-3-3ζ可以作为癌症治疗的新型分子靶标。为了有效的癌症治疗，需要开发新的方法，包括干扰14-3-3ζ客户相互作用的合成和/或天然抑制剂。

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