Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia

Hu Yu; Wang Xiuwen; Yu Shuang; Hou Yu; Ma Daoxin; Hou Ming

首页> 外文期刊>Expert opinion on therapeutic targets >Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia

【24h】

Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia

机译：IL-17A和IL-21的中和通过免疫性血小板减少症中与T-helper 17相关的信号通路调节调节性T细胞/ T-helper 17失衡

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Objective: The imbalance of regulatory T cell/T-helper 17 (Treg/Th17) is critical for the pathogenesis of immune thrombocytopenia (ITP) and IL-17A and IL-21 are overexpressed in ITP. The effects and mechanisms of IL-17A and IL-21 in Treg/Th17 imbalance and ITP pathophysiology are not clarified.

机译：目的：调节性T细胞/ T辅助物17（Treg / Th17）的失衡对于免疫性血小板减少症（ITP）的发病机制至关重要，并且IL-17A和IL-21在ITP中过表达。 IL-17A和IL-21在Treg / Th17失衡和ITP病理生理中的作用和机制尚不清楚。

著录项

来源
《Expert opinion on therapeutic targets》 |2015年第6期|共10页
作者
Hu Yu; Wang Xiuwen; Yu Shuang; Hou Yu; Ma Daoxin; Hou Ming;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
immune thrombocytopenia; regulatory T cell; T-helper 17; T-helper 17 cytokines;

机译：免疫性血小板减少症;调节性T细胞;T-helper 17;T-helper 17细胞因子;

相似文献

外文文献
中文文献
专利

1. Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia [J] . Hu Yu, Wang Xiuwen, Yu Shuang, Expert opinion on therapeutic targets . 2015,第6期

机译：IL-17A和IL-21的中和通过免疫性血小板减少症中与T-helper 17相关的信号通路调节调节性T细胞/ T-helper 17失衡
2. Programmed death 1/programmed cell death-ligand 1 pathway participates in gastric surgery-induced imbalance of T-helper 17/regulatory T cells in mice [J] . Dong Linlin, Zheng Xiaoyu, Wang Kun, The journal of trauma and acute care surgery . 2018,第3期

机译：编程死亡1 /编程的细胞死亡 - 配体1途径参与胃科手术诱导的小鼠T-Helper 17 /调节T细胞的不平衡
3. 18 beta-Glycyrrhetic Acid Modulates Th1/Th17/Th22/Regulatory T Cells Homeostasis Via HMGB1/NF-kappa B Signaling Pathway in Immune Thrombocytopenia [J] . Wang Haoyi, Zhao Yajing, An Ning, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：18β-甘草酸在免疫血小板减少症中通过HMGB1 / NF-Kappa B信号通路调节Th1 / Th17 / Th22 /调节T细胞稳态
4. Dissection of signal-regulated transcriptional modules by signaling pathway interference inoncogene-transformed cells [C] . Reinhold Schafer, Oleg I. Tchernitsa, Johannes Zuber, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：通过信号通路干扰incogene转化的细胞解析信号调节转录模块
5. CD4 dependent signaling regulates T-helper effector functions and cell death [D] . Tinsley, Kevin W. 2009

机译：CD4依赖性信号传导调节T辅助效应子功能和细胞死亡
6. Costimulatory molecule ICOS plays a critical role in the development of TH-17 and follicular T-helper cells by regulating c-Maf expression and IL-21 production [O] . Aurelie T. Bauquet, Hulin Jin, Alison M. Paterson, -1

机译：共刺激分子ICOS通过调节c-Maf表达和IL-21产生在TH-17和滤泡T辅助细胞的发育中起关键作用
7. T-Helper 17 Cell/Regulatory T-Cell Imbalance in COPD Combined with T2DM Patients [O] . Cheng Wang, Hong Wang, Luming Dai, 2021

机译：T-Helper 17 COPD中的细胞/调节T细胞不平衡与T2DM患者合并

Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia

摘要

著录项

相似文献

相关主题

期刊订阅