• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Gerontology >Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate
【24h】

Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate

机译：丙酸睾丸激素治疗对老年雄性大鼠的协调运动行为和黑质纹状体多巴胺能系统缺乏症，VMAT2表达上调

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of testosterone propionate (TP) supplements on the coordinated motor behavior and nigrostriatal dopaminergic (NSDA) system were analyzed in aged male rats. The present study showed the coordinated motor behavioral deficits, the reduced activity of NSDA system and the decreased expression of vesicular monoamine transporter 2 (VMAT2) in 24 month-old male rats. Long term TP treatment improved the motor coordination dysfunction with aging. Increased tyrosine hydroxylase and dopamine transporter, as well as dopamine and its metabolites were found in the NSDA system of TP-treated 24 month-old male rats, indicative of the amelioratory effects of TP supplements on NSDA system of aged male rats. The enhancement of dopaminergic (DAergic) activity of NSDA system by TP supplements might underlie the amelioration of the coordinated motor dysfunction in aged male rats. TP supplements up-regulated VMAT2 expression in NSDA system of aged male rats. Upregulation of VMAT2 expression in aged male rats following chronic TP treatment might be involved in the maintenance of DAergic function of NSDA system in aged male rats. (C) 2016 Elsevier Inc. All rights reserved.
机译：分析了老年雄性大鼠中丙酸睾丸激素（TP）补充剂对协调运动行为和黑质纹状体多巴胺能（NSDA）系统的影响。本研究显示了24个月大的雄性大鼠的协调运动行为缺陷，NSDA系统活性降低和水泡单胺转运蛋白2（VMAT2）表达降低。长期TP治疗可改善运动配合功能障碍并随年龄增长。在TP治疗的24个月大的雄性大鼠的NSDA系统中发现了酪氨酸羟化酶和多巴胺转运蛋白的增加，以及多巴胺及其代谢产物的增加，这表明TP补充剂对老年雄性大鼠NSDA系统的改善作用。 TP补充剂增强NSDA系统的多巴胺能（DAergic）活性可能是改善老年雄性大鼠协调性运动功能障碍的基础。 TP补充了成年雄性大鼠NSDA系统中VMAT2表达的上调。长期TP治疗后，老年雄性大鼠VMAT2表达上调可能参与了老年雄性大鼠NSDA系统的DA能功能维持。 （C）2016 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号