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首页> 外文期刊>Expert opinion on therapeutic targets >Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
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Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.

机译：酸性神经酰胺酶在前列腺癌中的上调：在肿瘤发展中的作用及其对治疗的意义。

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摘要

Bioactive sphingolipids, such as ceramide, sphingosine and sphingosine-1-phosphate are known bio-effector molecules which play important roles in various aspects of cancer biology including cell proliferation, growth arrest, apoptosis, metastasis, senescence and inflammation. Therefore, enzymes involved in ceramide metabolism are gaining recognition as being critical regulators of cancer cell growth and/or survival. We previously observed that the ceramide metabolizing enzyme, acid ceramidase (AC) is upregulated in tumor tissues. Studies have now concluded that this creates a dysfunctional ceramide pathway, which is responsible for tumor progression and resistance to chemotherapy and radiation. This suggests that development of small-molecule drugs that inhibit AC enzyme activity is a promising approach for improving standard cancer therapy and patient's clinical outcomes.
机译：生物活性鞘脂，例如神经酰胺，鞘氨醇和鞘氨醇-1-磷酸是已知的生物效应分子，其在癌症生物学的各个方面，包括细胞增殖，生长停滞，凋亡，转移，衰老和炎症中起重要作用。因此，参与神经酰胺代谢的酶已被认为是癌细胞生长和/或存活的关键调节剂。我们先前观察到，神经酰胺代谢酶酸性神经酰胺酶（AC）在肿瘤组织中上调。现在的研究得出的结论是，这会导致神经酰胺功能障碍，从而导致肿瘤进展以及对化学疗法和放射疗法的抵抗力。这表明开发抑制AC酶活性的小分子药物是改善标准癌症治疗和患者临床结局的有前途的方法。

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