• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on therapeutic targets >Multifunctional transcription factor YY1: a therapeutic target in human cancer?
【24h】

Multifunctional transcription factor YY1: a therapeutic target in human cancer?

机译：多功能转录因子YY1：人类癌症的治疗靶标？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The multifunctional transcription factor Yin Yang 1 (YY1) is a complex protein that has been shown to play pivotal roles in development, differentiation, cellular proliferation and apoptosis. It can act as a transcriptional repressor, an activator, or an initiator element binding protein that directs and initiates transcription of numerous cellular and viral genes. Because the expression and function of YY1 are known to be intimately associated with cell-cycle progression, the physiological significance of YY1 activity has recently been applied to models of cancer biology. Several lines of evidence imply that YY1 expression and/or activation is associated with tumourigenesis, in addition to its regulatory roles in normal biological processes. However, controversial results also raised and indicated that further studies are still needed to piece all of the seemingly contradictory data into a complete picture. On the basis of YY1 regulations and functions, novel drugs and specific treatment strategies may be developed with new therapeutic applications for tumour patients in the future.
机译：多功能转录因子Yin Yang 1（YY1）是一种复杂的蛋白质，已显示在发育，分化，细胞增殖和凋亡中起关键作用。它可以充当转录阻遏物，激活物或引发剂元件结合蛋白，来指导和启动众多细胞和病毒基因的转录。由于已知YY1的表达和功能与细胞周期进程密切相关，因此YY1活性的生理意义最近已应用于癌症生物学模型。几条证据表明，YY1的表达和/或激活与肿瘤的发生有关，除了它在正常生物学过程中的调控作用外。但是，有争议的结果也提出来了，表明仍然需要进一步的研究才能将所有看似矛盾的数据拼凑成一张完整的图片。根据YY1法规和功能，未来可能会开发出具有新治疗用途的新药和特定治疗策略，并将其应用于肿瘤患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号