Targeting invading macrophage-derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain.

Ma W; Quirion R

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Targeting invading macrophage-derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain.

机译：在受伤的神经中靶向巨噬细胞衍生的PGE2，IL-6和降钙素基因相关肽，以治疗神经性疼痛。

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Immune and inflammatory responses occurring in an injured nerve have been generally believed to contribute to the generation and maintenance of neuropathic pain. In this review, the authors demonstrate the upregulation of COX-2/prostaglandin E2, IL-6 and calcitonin gene-related peptide in invading macrophages and discuss possible mechanisms involved in their upregulation and how they contribute to the maintenance of neuropathic pain. By acting on nociceptors in dorsal root ganglion and local inflammatory cells via autocrine or paracrine pathways, these inflammatory mediators facilitate spontaneous ectopic activity and sustain nociceptive responses, an important mechanism underlying both ongoing and evoked neuropathic pain state. Targeting these mediators in injured nerve may provide novel therapeutic avenues to more successfully treat nerve injury-associated neuropathic pain.

机译：通常认为在受伤的神经中发生的免疫和炎症反应有助于神经性疼痛的产生和维持。在这篇综述中，作者证明了侵袭性巨噬细胞中COX-2 /前列腺素E2，IL-6和降钙素基因相关肽的上调，并讨论了其上调涉及的可能机制以及它们如何有助于维持神经性疼痛。这些炎症介质通过自分泌或旁分泌途径作用于背根神经节和局部炎症细胞中的伤害感受器，从而促进自发性异位活性并维持伤害感受性反应，这是正在进行的和诱发的神经性疼痛状态的重要机制。在受伤的神经中靶向这些介体可能会提供新的治疗途径，以更成功地治疗与神经损伤相关的神经性疼痛。

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《Expert opinion on therapeutic targets》 |2006年第4期|共14页
作者
Ma W; Quirion R;
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正文语种 eng
中图分类药学;
关键词
Pain; Nerve; Peptides; Interleukin-6; Genes; 疼痛; 肽类; 白细胞介素6; 基因;

机译：Pain;Nerve;Peptides;Interleukin-6;Genes;疼痛;肽类;白细胞介素6;基因;

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专利

1. Targeting invading macrophage-derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain. [J] . Ma W, Quirion R Expert opinion on therapeutic targets . 2006,第4期

机译：在受伤的神经中靶向巨噬细胞衍生的PGE2，IL-6和降钙素基因相关肽，以治疗神经性疼痛。
2. Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related Peptide expression in a rat model of wrist joint inflammatory pain. [J] . Iwakura N, Ohtori S, Orita S, Journal of Hand Surgery. American Volume . 2010,第2期

机译：低亲和神经生长因子受体抑制性抗体在腕关节炎性疼痛大鼠模型中减轻疼痛行为和降钙素基因相关肽表达的作用。
3. Distinct calcitonin gene-related peptide expression pattern in primary afferents contribute to different neuropathic symptoms following chronic constriction or crush injuries to the rat sciatic nerve [J] . Yu Zou, Fangting Xu, Zhaohui Tang, Molecular pain . 2016,第4期

机译：慢性收缩或压迫大鼠坐骨神经损伤后，原发传入中降钙素基因相关的肽表达模式不同，导致不同的神经病理症状
4. Fmoc Solid-Phase Peptide Synthesis of Human a-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs [C] . M. Fuente-Moreno, A. Oddo, M. Sheykhzade American Peptide Symposium . 2015

机译：FMOC固相肽合成人A-Calcitonin基因相关肽和两个荧光类似物
5. Characterization of the gene for the calcitonin gene-related peptide (CGRP) receptor component protein (RCP), and generation of RCP +/- embryonic stem cells. [D] . Mnayer, Laila Omar. 2003

机译：降钙素基因相关肽（CGRP）受体成分蛋白（RCP）的基因表征以及RCP +/-胚胎干细胞的生成。
6. Pulsed Radiofrequency Applied to the Sciatic Nerve Improves Neuropathic Pain by Down-regulating The Expression of Calcitonin Gene-related Peptide in the Dorsal Root Ganglion [O] . Hao Ren, Hailong Jin, Zipu Jia, 2018

机译：脉冲射频施加于坐骨神经通过下调背根神经节中降钙素基因相关肽的表达改善神经性疼痛
7. Pulsed Radiofrequency Applied to the Sciatic Nerve Improves Neuropathic Pain by Down-regulating The Expression of Calcitonin Gene-related Peptide in the Dorsal Root Ganglion [O] . Hao Ren, Hailong Jin, Zipu Jia, 2018

机译：施加到坐骨神经的脉冲射频通过降低反旋翼基因相关肽在背根神经节中的表达来改善神经性疼痛
8. Differential Expression of Calcitonin Gene-Related Peptide, a-CGRP mRNA, Choline Acetyltransferase, and Low Affinity Nerve Growth Factor Receptor in Cranial Motoneurons After Hypoglossal Nerve Injury During Postnatal Development. [R] . Blake-Bruzzini, K. M. 1996

机译：生长发育过程中舌下神经损伤后颅内运动神经元中降钙素基因相关肽，α-CGRp mRNa，胆碱乙酰转移酶和低亲和神经生长因子受体的差异表达。

Targeting invading macrophage-derived PGE2, IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic pain.

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