• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on therapeutic targets >Rogue proliferation versus restorative protection: where do we draw the line for Wnt and forkhead signaling?
【24h】

Rogue proliferation versus restorative protection: where do we draw the line for Wnt and forkhead signaling?

机译：恶意扩散与恢复保护：我们在哪里划定Wnt和forkhead信号线？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Disease entities such as diabetes, neurodegeneration and cardiovascular disorders affect a significant portion of the world's population. OBJECTIVE: Given that cellular survival and longevity in multiple disorders are tied to oxidative stress, apoptotic cell injury and immune system deregulation, the development of robust therapeutic strategies rests heavily upon the ability to balance each of these parameters. METHODS: Here we discuss two exciting signaling pathways, namely Wnt and mammalian forkhead transcription factors predominantly of the O class superfamily, which can share integrated cytoprotective pathways during oxidative stress but may also adversely influence cellular survival and promote cancer cell proliferation. CONCLUSION: Future investigations must elucidate the cellular determinants that govern the ability of Wnt and forkhead proteins to promote cellular longevity and possible disease remission but also allow for detrimental biological consequences and clinical compromise.
机译：背景：诸如糖尿病，神经退行性疾病和心血管疾病之类的疾病实体影响着世界人口的很大一部分。目的：鉴于多种疾病的细胞存活和长寿与氧化应激，凋亡性细胞损伤和免疫系统失调有关，因此强有力的治疗策略的发展很大程度上取决于平衡这些参数的能力。方法：在这里，我们讨论了两个激动人心的信号通路，即Wnt和主要是O类超家族的哺乳动物叉头转录因子，它们在氧化应激期间可以共享整合的细胞保护途径，但也可能不利地影响细胞存活并促进癌细胞增殖。结论：未来的研究必须阐明控制Wnt和叉头蛋白促进细胞寿命和可能的疾病缓解的能力的细胞决定因素，同时也要考虑有害的生物学后果和临床危害。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号