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Initiation of protein synthesis: A target for antimicrobials

机译：蛋白质合成的开始：抗菌药物的目标

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Background: Translation initiation is a basic and universal biological process that employs significantly different components and displays substantially different mechanisms in bacterial, archaeal and eukaryotic cells. A large amount of detailed mechanistic and structural information on the bacterial translation initiation apparatus has been uncovered in recent years. Objective: to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs. Methods: Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation are presented. Results/conclusions: Considerations and predictions concerning a future scenario for research and identification of bacterial translation initiation inhibitors are presented.
机译：背景：翻译起始是一个基本且普遍的生物学过程，在细菌，古细菌和真核细胞中采用显着不同的成分并表现出显着不同的机制。近年来，已经发现了有关细菌翻译起始装置的大量详细的机械和结构信息。目的：了解哪些翻译起始步骤可以代表发现新的和特定的抗菌药物的新靶标或开发不足的靶标。方法：简要介绍了主要抗生素的特性和作用机理，这些抗生素对细菌的翻译起始具有直接的抑制作用。结果/结论：提出了有关细菌翻译起始抑制剂研究和鉴定的未来方案的考虑和预测。

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