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首页> 外文期刊>Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association >IL-6 serum levels predict postoperative morbidity in gastric cancer patients.
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IL-6 serum levels predict postoperative morbidity in gastric cancer patients.

机译：IL-6血清水平可预测胃癌患者的术后发病率。

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摘要

BACKGROUND: Despite progress in surgical techniques and perioperative care, gastrectomy remains a procedure of significant morbidity. Several scoring systems and clinical measures have been adopted to predict postoperative complications in gastric cancer patients. The aim of this study was to investigate whether high serum levels of interleukin 6 (IL-6) in the early postoperative period may be a prognostic factor of postoperative morbidity. METHODS: A group of 99 consecutive patients with resectable gastric cancer were enrolled. The mean age was 62.9 years and the male/female ratio was 72:27. Subtotal gastric resection was performed in 22 patients and total gastric resection in 77. The IL-6 serum level was measured on the 1st postoperative day (POD). RESULTS: Complications were recorded in 28 patients (28.3%). The observed case-fatality rate was 3.03%. An IL-6 serum level of >288.7 pg/ml on the 1st POD in univariate and multivariate Cox proportional hazard models was an independent prognostic factor for overall complications and infective complications. CONCLUSION: Our study showed an association between perioperative IL-6 serum levels and postoperative morbidity in gastric cancer patients. The IL-6 serum level on the 1st POD was shown to be an independent prognostic factor for both overall complications and infective complications.
机译：背景：尽管外科手术技术和围手术期护理取得了进展，但胃切除术仍然是一个发病率很高的手术。已经采用了几种评分系统和临床措施来预测胃癌患者的术后并发症。这项研究的目的是调查术后早期血清白细胞介素6（IL-6）的高血清水平是否可能是术后发病的预后因素。方法：一组99例连续可切除的胃癌患者入组。平均年龄为62.9岁，男女比例为72:27。在22例患者中进行了次全胃切除术，在77例中进行了全胃切除术。在术后第一天（POD）测量了IL-6血清水平。结果：28例患者发生并发症（28.3％）。观察到的病死率为3.03％。在单变量和多变量Cox比例风险模型中，第1个POD的IL-6血清水平> 288.7 pg / ml，是总体并发症和感染性并发症的独立预后因素。结论：我们的研究表明胃癌患者围手术期IL-6血清水平与术后发病率之间存在相关性。第1个POD上的IL-6血清水平是总体并发症和感染性并发症的独立预后因素。

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