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首页> 外文期刊>European Journal of Obstetrics, Gynecology and Reproductive Biology: An International Journal >Gene expression patterns of insulin-like growth factor 1, 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in human placenta from preterm deliveries: Influence of additional factors
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Gene expression patterns of insulin-like growth factor 1, 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in human placenta from preterm deliveries: Influence of additional factors

机译：早产中胎盘中胰岛素样生长因子1、2（IGF-1，IGF-2）和胰岛素样生长因子结合蛋白3（IGFBP-3）的基因表达模式：其他因子的影响

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Objective: To compare patterns of human placental gene expression of IGF from pregnancies that ended with preterm delivery vs. full term pregnancies as controls. Study design: Real-time PCR was used to assess gene expression of IGF in human placental samples from 104 preterm and 140 full term pregnancies. Results: In the preterm delivery group, the proportion of smokers was significantly higher than in the control group. A history of preterm delivery was more common in the preterm delivery group compared to the control group. In the preterm delivery group, placental samples showed an underexpression of the IGF-1 gene compared to controls. In cases of male fetal gender an overexpression of both the IGF-2 and the IGFBP-3 genes was observed. Conclusion: Among environmental factors influencing preterm delivery, smoking was the most significant in our study. In the majority of cases, preterm delivery was induced by intrauterine infection leading to a decreased activity of the IGF system. This mechanism may also play a role in the development of neurological sequelae and in decreased tolerance to fetal distress. The overexpression of the IGF-2 gene observed in the placenta with male fetal gender can be explained by its physiological role in the development of the male phenotype.
机译：目的：比较以足月妊娠和以足月妊娠为对照的妊娠中IGF的人胎盘基因表达模式。研究设计：实时荧光定量PCR用于评估104例早产和140例足月妊娠的人胎盘样本中IGF的基因表达。结果：早产组的吸烟者比例明显高于对照组。与对照组相比，早产组中早产史更为普遍。在早产组中，与对照相比，胎盘样品显示IGF-1基因表达不足。在男性胎儿性别的情况下，观察到IGF-2和IGFBP-3基因均过表达。结论：在影响早产的环境因素中，吸烟是我们研究中最重要的因素。在大多数情况下，宫内感染可导致早产，导致IGF系统活性降低。该机制也可能在神经后遗症的发展和对胎儿窘迫的耐受性降低中起作用。在具有男性胎儿性别的胎盘中观察到的IGF-2基因过表达可以用其在男性表型发展中的生理作用来解释。

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